A study of 228,876 pregnancies, published in the July issue of the American journal of Obstetrics & Gynecology, finds that maternal antidepressant use is associated with shortened (4-5 days) gestational age; for each prescription filled in the second trimester, the risk of early labor doubled. In the third trimester, antidepressant use was associated with an elevated risk of infant convulsions.
Hayes, R., Wu, P., et al; “Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies,” American Journal of Obstetrics & Gynecology Vol. 207(1) 49.e`-49.e9, July 2012
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