Danish research found a significantly increased risk of congenital heart defects in both the 4,183 pregnancies exposed to SSRIs throughout the first trimester and the 806 pregnancies for which SSRI use had been discontinued. The study acknowledges insufficient data to make conclusions about causality or possible confounding factors. The full study is available online from the British Medical Journal.

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Jimenez-Solem, E., Andersen, J., et al; “Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study.” BMJ Open, 2012;2:e001148