Outcome of Mood Disorders Before Psychopharmacology

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A "systematic review" of all outcome studies of patients with mood disorders, in the March issue of the Australia & New Zealand Journal of...

SSRIs Cause Epilepsy in Rats

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Researchers from Australia find that chronic treatment with SSRIs significantly increases the rate of epileptogenesis in rats.  Although SSRIs are commonly prescribed to people...

Antidepressant Use Associated with Brain Atrophy and Lesions in Elderly

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In a study of 630 elderly Manhattanites without dementia, researchers from the Netherlands found that antidepressant use was associated with significantly more brain atrophy,...

SSRIs Can Impair New Learning About Anxiety

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Researchers from Columbia University and the New York State Psychiatric Institute test the behavioral effects of SSRIs on Pavlovian fear conditioning in rats, and...

Anticholinergic Drugs, Including Antidepressants, Linked To Later Cognitive Problems

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A new study, published in JAMA Neurology, found that older people who regularly took anticholinergic drugs, including certain cold medicines or antidepressants, had poorer...

Identifying Psychiatric Drugs Leading to Emergency Room Visits

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More than ten-percent of adults in the United States are currently prescribed at least one psychiatric medication but there is currently a lack of research on the prevalence of adverse drug events (ADEs) associated with these prescriptions outside of clinical trials.

GSK to Face Class Action over Antidepressants for Children

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A Sydney, Australia law firm has launched a class action on behalf of people who as children and adolescents were prescribed Glaxosmithkline's drug Paroxetine. Despite...

Therapy More Effective than Medications for Anxiety — Placebos Also Effective

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One-on-one Cognitive Behavioral Therapy is better than psychiatric medications or other common psychotherapeutic interventions for severe anxiety disorders in adults, according to a large...

Antidepressants Seem to Increase Heart Disease in the Elderly

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Depressed elderly people are more likely to suffer heart disease not because of their depression, but apparently due to antidepressant drugs.

Antidepressants Tied To Increased Risk of Homicide “Only Modestly”; Benzodiazepines More So

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Taking antidepressant or benzodiazepine medications increases the risks that a person will commit a homicide, according to a study from Finland published in a World Psychiatry letter.

Researchers Investigate Antidepressant-Induced Suicidal Ideation

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An increase in suicidal thoughts is a known and serious side-effect for various types of antidepressants. Recent studies suggest that there may be some...

Fava: Antidepressants in Severe Cases, Short Duration Only

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Giovanni Fava has published an integrative analysis of the different sources of scientific research into antidepressants in Psychotherapy and Somatics. “The use of antidepressant...

Antidepressants Not a ‘One Size Fits All’ Solution, Researchers Find

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The largest ever study of the thoughts and reactions of antidepressant users reveals that many people have vastly different understandings and experiences of the...

SSRI Antidepressants Appear to Raise Risk of Serious Respiratory Disease in Newborns

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A new study has reinforced earlier warnings that taking SSRI antidepressants late in pregnancy appears to put mothers at a slightly increased risk of having newborns with persistent pulmonary hypertension.

New Form of Mice Experiment Reveals Antidepressant’s Dangers Earlier

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Scientists from the University of Utah say they have discovered a new way of doing mice experiments that more sensitively and quickly reveals negative...

SSRIs Increase Post-Surgical Complications

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A study of 530,000 patients who underwent surgery at 375 U.S. hospitals found a 10% increased risk of post-operative complications including bleeding, transfusion, hospital...

Publication Bias in Literature on Antidepressants for Autism

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Researchers at the University of Michigan reviewed published and unpublished trials of serotonin receptor inhibitors (SRI) for the treatment of autism spectrum disorders (ASD)....

SSRIs: More Harm Than Good

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Beginning with an "evolutionary analysis" and a review of serotonin's role in the body, researchers from Canada and the U.S. conduct a thorough review...

Treating Anxiety by Tapering Off Antidepressants

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Researchers from Samaritan Mental Health in Corvallis, Oregon successfully treated 12 patients for anxiety by discontinuing their antidepressant medications. Some received alternative medications for...

FDA Pans Depression Patch For Children and Teens

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The FDA released a report in July of a trial on children and adolescents of the selegiline (Emsam) transdermal patch for treatment of depression,...

Reanalysis of Data Shows Antidepressant Impacts on Depression “Not Clinically Significant”

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Irving Kirsch and Joanna Moncrieff have reanalyzed the clinical trial data on antidepressants.

High Doses of Antidepressants Increase Self-Harm in Children, Young Adults

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A comprehensive meta-analysis of randomized trial data by researchers from the Harvard School of Public Health finds that children and young adults who start...

Int’l Task Force Doesn’t Endorse Antidepressants for Bipolar

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Noting a "striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar,"...

Antidepressant Use and Cognitive Impairment After Menopause

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A study of 6,998 postmenopausal women followed over 7.5 years found that antidepressant use correlated with a 70% increased risk of cognitive impairment. The...

Study of Antidepressants and Suicide is Retracted

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A controversial 2010 paper, "Antidepressant Medication Prevents Suicide in Depression", has been retracted by Acta Psychiatrica Scandinavica. In a contemporaneous issue of British Journal of...