Withdrawal from Antidepressants

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A review of the scientific literature related to withdrawal from antidepressants: mechanism of action; long-term effects of exposure to antidepressants; discontinuation syndromes; relapse upon discontinuation; tapering protocols.

Psych Med Prescribing After Perinatal/Neonatal Death

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Research from MIA blogger Jeffrey Lacasse finds that "at present, there exists no rigorous evidence to support the prescription of Ads (antidepressants) in bereavement....

FDA: Antidepressant Trials Have Not Adequately Reported Sexual Dysfunction Side Effects

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US Food and Drug Administration scientists want to better evaluate side effects of sexual dysfunction associated with antidepressant drugs.

Therapy Beats Drugs for Depression for Long-Term Outcomes

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Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.

SSRIs: More Harm Than Good

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Beginning with an "evolutionary analysis" and a review of serotonin's role in the body, researchers from Canada and the U.S. conduct a thorough review...

Tapering Strips Help People Stop Using Antidepressants, Study Finds

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A new study by Peter Groot and Jim van Os investigated whether tapering strips can help people stop using antidepressants.

Women on SSRIs Less Likely To Breastfeed

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In a prospective cohort study of 466 pregnant women over 10 years, researchers at the California Teratogen Information Service found that women exposed to...

Infants Exposed to Psychotropic Drugs During Pregnancy At Risk

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New research published in the July issue of The Journal of Clinical Psychiatry found that the use of mood stabilizers, antipsychotics, antidepressants, and hypnotics during pregnancy is associated with increased health risks to the infant.

Researchers Ask, ‘Why Do Antidepressants Stop Working?’

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An international group of researchers, including several with financial ties to manufacturers of antidepressants, explore possible explanations for why long-term users of antidepressants become chronically depressed.

New Form of Mice Experiment Reveals Antidepressant’s Dangers Earlier

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Scientists from the University of Utah say they have discovered a new way of doing mice experiments that more sensitively and quickly reveals negative...
brain against blue dna strand with chemical structures

No Difference in Antidepressant Effectiveness After Genetic Testing

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Genetic testing may help reduce the length of time people experience the harmful effects of antidepressant drugs, but it is not helpful for predicting efficacy.

Antidepressant Exposure In Utero May Negatively Impact Motor Skills in 2-Year-Old Children

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A new study in Frontiers of Pharmacology finds that antidepressant use during pregnancy is linked to reduced motor skills in children at 2 years...
Man closely examing instructions on prescription medications

Antidepressant-Induced Serotonin Syndrome a Danger for the Elderly

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Researchers found that 25% of elderly patients taking antidepressants had serotonin syndrome, which is potentially life-threatening.

Many People Taking Antidepressants Don’t Have Any Mental Disorders

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The majority of people taking antidepressant medications have never had major depressive disorder, and 38% have never met criteria for having any mental disorder.

No Good Evidence That Antidepressants Prevent Relapse

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Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Researchers: Antidepressant Use in Children Increases Suicide, No Evidence of Benefit

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Noted antidepressant researcher, Michael Hengartner, summarizes the latest research on the use of antidepressants in children and adolescents.

Antidepressant Made Germanwings Co-pilot “Panic”

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Germanwings pilot Andreas Lubitz wrote, in a desperate, final email to his psychiatrist two weeks before slamming his A320 jet into the French Alps...

JAMA Psychiatry Retracts Antidepressant Study

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Once an appropriate statistical method was used, the study findings were “no longer valid,” according to the editors of JAMA and JAMA Psychiatry.

Antidepressant Use in Pregnancy Harms Child Development, Untreated Maternal Depression Shows Benefit

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In this new study, exposure to maternal anxiety in utero also harmed child development.

Antidepressants in Pregnancy: Risks to the Fetus and Long-term Health of the Child

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The research literature reveals that antidepressant use in pregnancy poses considerable risks to the fetus and the long-term health of the child. These risks include preterm birth, birth defects, abnormal brain development, and behavioral abnormalities in early childhood.

Autism Linked to Antidepressants During Pregancy

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A study of the Swedish medical birth registry, conducted by researchers from Sweden, the U.K., and the U.S.A., found a 3.3X greater risk of...

Cumulative Risk of Impairment and Death From Anticholinergic Medication

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The New York Times reports that a two-year longitudinal study of over 13,000 men and women over 65 found that anticholinergic medications, which include many...

Researchers Find Paroxetine Harms Developing Brain

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Researchers at Johns Hopkins test paroxetine on developing brain cells and discover numerous neurotoxic effects.

Treating Anxiety by Tapering Off Antidepressants

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Researchers from Samaritan Mental Health in Corvallis, Oregon successfully treated 12 patients for anxiety by discontinuing their antidepressant medications. Some received alternative medications for...

Increased Risk of Preterm Birth in Women Taking Antidepressants

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A detailed meta-analysis of the published research on women taking antidepressants during pregnancy finds that the rate of preterm birth is nearly doubled in the third...