Thank you, Bob, for this deeply moving piece. I say this as someone who worked as a neuroscientist for nearly 25 years, before closing down my laboratory in 2000, as I did not think that drug treatments for so-called psychiatric conditions were of value. I still work in the field of mental health – I prefer the expression ‘social and emotional wellbeing’ – addiction and trauma, just in a very different way to before. I am so glad I made that career change. RIP, Zel. You are a remarkable man and your words will add to the tide of change.