Thursday, December 3, 2020

Science News: Psychiatric Drugs

 

New FDA Study Shows Benzodiazepines Can Cause Long-Term Injury

The FDA has finally acknowledged the adverse effects of benzodiazepines, the dangers of withdrawal, and that the current packaging does not sufficiently warn of these harms.

Suicide Rates Did Not Decrease When Antidepressant Drugs Were Introduced

Researchers investigate the claim that the introduction of antidepressant drugs led to decreases in suicide rates internationally.

A Short History of Tardive Dyskinesia: 65 Years of Drug-Induced Brain Damage That Rolls...

Psychiatry has long turned a blind eye to the full scope of harm associated with TD. New TD drugs "work" by further impairing brain function.

Increasing Numbers of Children Prescribed Multiple Psychiatric Medications

According to researchers, children are being increasingly prescribed multiple different psychiatric medications.

The Latest “Breakthrough Therapy”: Expensive New Drugs for Tardive Dyskinesia

The increased prescribing of antipsychotics, which frequently cause a brain injury that manifests as tardive dyskinesia, has provided pharmaceutical companies with a lucrative new market opportunity.

Promising Preliminary Results from a Small Study of Psilocybin-Assisted Therapy

A new study offers promising results for psilocybin-assisted psychotherapy for depression.

Researchers: Antidepressant Use in Children Increases Suicide, No Evidence of Benefit

Noted antidepressant researcher, Michael Hengartner, summarizes the latest research on the use of antidepressants in children and adolescents.

Surviving Antidepressants: An Interview with Adele Framer

That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.

Anticholinergic Drugs Increase Risk of Cognitive Decline

A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.

Researchers: It’s Time to Stop Recommending Antidepressants for Depression

Researchers review a new synthesis of the existing evidence and conclude that the harms of antidepressants outweigh any benefits.
antipsychotic drugs

Antipsychotic Augmentation Increases Risk of Death

A new study finds that adding an antipsychotic to existing antidepressant treatment is associated with a 45% increased risk of early death.

Greater Exposure to Antipsychotics Associated with Worse Long-Term Outcomes

A new study finds adverse long-term consequences associated with the increased use of antipsychotics in first-episode psychosis.

Psychiatry’s Top Experts Acknowledge Lasting Harms of Antidepressant Withdrawal

Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

Further Results Confirm Antidepressants Increase Risk of Violent Crime By 26%

Taking an SSRI antidepressant was associated with a 26% increased risk of violent crime conviction.

Unblinding in Antidepressant Trials Biases Results

Studies that compare the effectiveness of different antidepressant drugs are unreliable, according to new research in BMC Psychiatry.

Stuart Shipko – SSRI Withdrawal: Shooting the Odds

We interview Dr. Stuart Shipko, a psychiatrist and author who has a particular interest in the side effects and withdrawal effects of SSRI antidepressants and the need for informed consent when prescribing.

Tapering Strips Help People Stop Using Antidepressants, Study Finds

A new study by Peter Groot and Jim van Os investigated whether tapering strips can help people stop using antidepressants.

Very Slow Taper Best for Antipsychotic Discontinuation

An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

An FDA Whistleblower’s Documents: Commerce, Corruption, and Death

In 2008, a reviewer of psychiatric drugs at the FDA, Ron Kavanagh, complained to Congress that the FDA was approving a new antipsychotic that was ineffective and yet had adverse effects that increased the risk of death. Twelve years later, a review of the whistleblower documents reveal an FDA approval process that can lead to the marketing of drugs sure to harm public health.

Antipsychotics Associated with Severe COVID-19 and Fatal Outcomes

A new study has found a strong association between antipsychotic drugs and higher rates of severe cases of COVID-19.

Suicide Rates Did Not Decrease When Antidepressant Drugs Were Introduced

Researchers investigate the claim that the introduction of antidepressant drugs led to decreases in suicide rates internationally.

Promising Preliminary Results from a Small Study of Psilocybin-Assisted Therapy

A new study offers promising results for psilocybin-assisted psychotherapy for depression.

Researchers: Antidepressant Use in Children Increases Suicide, No Evidence of Benefit

Noted antidepressant researcher, Michael Hengartner, summarizes the latest research on the use of antidepressants in children and adolescents.

Surviving Antidepressants: An Interview with Adele Framer

That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.

Anticholinergic Drugs Increase Risk of Cognitive Decline

A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.

Researchers: It’s Time to Stop Recommending Antidepressants for Depression

Researchers review a new synthesis of the existing evidence and conclude that the harms of antidepressants outweigh any benefits.

Psychiatry’s Top Experts Acknowledge Lasting Harms of Antidepressant Withdrawal

Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

Further Results Confirm Antidepressants Increase Risk of Violent Crime By 26%

Taking an SSRI antidepressant was associated with a 26% increased risk of violent crime conviction.

Unblinding in Antidepressant Trials Biases Results

Studies that compare the effectiveness of different antidepressant drugs are unreliable, according to new research in BMC Psychiatry.

Stuart Shipko – SSRI Withdrawal: Shooting the Odds

We interview Dr. Stuart Shipko, a psychiatrist and author who has a particular interest in the side effects and withdrawal effects of SSRI antidepressants and the need for informed consent when prescribing.

Tapering Strips Help People Stop Using Antidepressants, Study Finds

A new study by Peter Groot and Jim van Os investigated whether tapering strips can help people stop using antidepressants.

Strategies for Tapering and Discontinuing Antidepressants

A new review of strategies to support both patients and practitioners through the process of discontinuing antidepressants.

Youth Antidepressant Use Associated With Increased Suicide and Self-Harm

National data on rates of youth antidepressant prescription, suicide, and self-harm in Australia sparks public health debate about drug safety.

Study Finds SSRIs Associated with Increased Risk for Violent Crime

Study finds an apparent connection between SSRIs, the most commonly prescribed type of antidepressant, and increased risk of violent crime.

JAMA Psychiatry Retracts Antidepressant Study

Once an appropriate statistical method was used, the study findings were “no longer valid,” according to the editors of JAMA and JAMA Psychiatry.

New Analysis: Antidepressants Still Linked to Suicide

“This is remarkable for drugs that are used to treat depressive symptoms,” write the researchers.

New Algorithms Fail to Predict Antidepressant Treatment Outcomes

Researchers suggest that because most antidepressant “success” is due to the placebo effect, they may never find a way to predict outcomes.

No Good Evidence That Antidepressants Prevent Relapse

Trials of antidepressants for relapse prevention are confounded by withdrawal effects caused by the drugs.

Antidepressant Misinformation Promoted on Popular Websites

A new study indicates that popular online resources do not accurately present the scientific evidence on the risks and benefits of antidepressants.

Antidepressant Use Continues to Climb Among Youth on Medicaid

New study finds that Medicaid enrolled youth were 14 times more likely to be on an antidepressant in 2014 than in 1987.

A Short History of Tardive Dyskinesia: 65 Years of Drug-Induced Brain Damage That Rolls...

Psychiatry has long turned a blind eye to the full scope of harm associated with TD. New TD drugs "work" by further impairing brain function.

The Latest “Breakthrough Therapy”: Expensive New Drugs for Tardive Dyskinesia

The increased prescribing of antipsychotics, which frequently cause a brain injury that manifests as tardive dyskinesia, has provided pharmaceutical companies with a lucrative new market opportunity.

Anticholinergic Drugs Increase Risk of Cognitive Decline

A new study finds that anticholinergic drugs, like antidepressants and antipsychotics, are associated with mild cognitive decline.
antipsychotic drugs

Antipsychotic Augmentation Increases Risk of Death

A new study finds that adding an antipsychotic to existing antidepressant treatment is associated with a 45% increased risk of early death.

Greater Exposure to Antipsychotics Associated with Worse Long-Term Outcomes

A new study finds adverse long-term consequences associated with the increased use of antipsychotics in first-episode psychosis.

Very Slow Taper Best for Antipsychotic Discontinuation

An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

An FDA Whistleblower’s Documents: Commerce, Corruption, and Death

In 2008, a reviewer of psychiatric drugs at the FDA, Ron Kavanagh, complained to Congress that the FDA was approving a new antipsychotic that was ineffective and yet had adverse effects that increased the risk of death. Twelve years later, a review of the whistleblower documents reveal an FDA approval process that can lead to the marketing of drugs sure to harm public health.

Antipsychotics Associated with Severe COVID-19 and Fatal Outcomes

A new study has found a strong association between antipsychotic drugs and higher rates of severe cases of COVID-19.

For People “At Risk for Psychosis,” Antipsychotics Associated with Worse Outcomes

Researchers studied whether antipsychotics could prevent transition to full psychosis and found that the drugs worsened outcomes.

Randomized Controlled Trial Confirms That Antipsychotics Damage the Brain

A new study published in JAMA Psychiatry connects antipsychotics with damage to the brain in multiple areas.

Do Antipsychotics Protect Against Early Death? A Review of the Evidence

Psychiatry is now claiming that research has shown that antipsychotics reduce mortality among the seriously mentally ill. A critical review of the literature reveals that this claim is best described as the the field's latest "delusion" about the merits of these drugs.

Antipsychotic Trials Show Increasing Placebo Response and Declining Drug Response

A new review of antipsychotic trials conducted over the last 24 years finds that the placebo response rate is steadily increasing, and drug response is decreasing.

Does Longer Duration of Untreated Psychosis Cause Worse Outcomes?

New research counters the long-held assumption that a longer duration of untreated psychosis is associated with worse outcomes.

Largest Survey of Antipsychotic Experiences Reveals Negative Results

A new survey exploring antipsychotic user experience finds that more than half of the participants report only negative experiences.

Review Explores First-Person Experiences of People Taking Antipsychotics

A new systematic review finds that patients report reduced symptoms but also loss of self and agency while taking antipsychotics.

The Charade of New Drug Approvals for Schizophrenia

The FDA recently approved lumateperone for schizophrenia. A review of the clinical trials reveals a testing process that is fatally flawed, and a new drug coming to market that doesn't provide a clinically meaningful benefit.

Relapse in Antipsychotic Drug Trials is Poorly Defined

There is a lack of consensus in the definition of ‘relapse’ across randomized controlled trials of antipsychotic maintenance treatment for schizophrenia and psychosis.
digital antipsychotic

The Rise of the Digital Asylum

The digital pill Abilify MyCite, which is now being introduced into the market, foretells of a future where such technology is used to monitor the behavior, location and "medication compliance" of a person 24 hours a day.

How Do We Test the Effects of Long-Term Exposure to Antipsychotics?

A new attempt to study the neurological effects of long-term exposure to antipsychotics uses healthy volunteers on minimal doses for 15 days.

How Exercise Can Help With First Episode Psychosis

New study examines the experiences of people utilizing an exercise program following a first-episode psychosis.

New FDA Study Shows Benzodiazepines Can Cause Long-Term Injury

The FDA has finally acknowledged the adverse effects of benzodiazepines, the dangers of withdrawal, and that the current packaging does not sufficiently warn of these harms.

World Benzodiazepine Awareness Day 2020

This week on MIA Radio, we present the second part of our podcast to join in the events for World Benzodiazepine Awareness Day 2020...

Benzodiazepines Linked to More Emergency Department Visits

Recent research implicates benzodiazepines as being involved in a high rate of emergency department visits in the US.

Benzodiazepine Prescriptions in Older Adults Used in Rural and Low Income Areas

Benzodiazepine prescription practices may be in response to an epidemic of distress, rather than being used to treat specific mental health diagnoses.

Nonclinical Factors are Associated with Long-Term Benzodiazepine Use in Older Adults

White race and size of initial prescription, along with poor sleep quality, are associated with long-term benzodiazepine use in older adults.

Psychiatrists Warn Policymakers Benzodiazepine Overuse Could Lead to Next Epidemic

Although opioid addiction and overuse have garnered significant national attention, similar trends in benzodiazepine overprescription and overuse continue to go unnoticed.

Cognitive Impairment from Long-Term Benzodiazepine Use Remains Even After Drug Withdrawal

Long-term benzodiazepine use shown to effect cognitive function during current use and for years after drug discontinuation.

Preventing Long-term Benzodiazepine Use

Researchers Identify risk factors for long-term benzodiazepine use to prevent harmful effects.

Researchers Identify Patterns in Antidepressant and Long-Term Benzodiazepine Use

The researchers found that, of those who were initially prescribed both antidepressants and benzodiazepines, approximately 12% went on to engage in long-term benzodiazepine use.

Prescribing Benzodiazepines As-Needed Leads to Abuse

A new study reported on in Medscape, examined risk factors for misuse of benzodiazepines (drugs such as Xanax, Ativan, and Klonopin). The researchers found that patients who had been prescribed the medication on an as-needed basis were more likely to end up abusing it than those who had been prescribed a standing dose.

Withdrawal from Benzodiazepines

A review of the scientific literature related to withdrawal from benzodiazepines, including studies of protracted withdrawal symptoms and risk of relapse related to tapering procedures.

Hypnotic Medications Linked to Suicide Risk

A recent review found that hypnotic medications are associated with risks of suicide and suicidal ideation.

Is Long-term Use of Benzodiazepines a Risk for Cancer?

A large study of the population in Taiwan reveals that long-term use of benzodiazepine drugs, commonly prescribed for anxiety, significantly increases the risk for brain, colorectal, and lung cancers. The research, published open-access in the journal Medicine, also identifies the types of benzodiazepines that carry the greatest cancer risk.

Benzodiazepine Prescriptions Increase with Overdose Deaths

A recent article in the American Journal of Public Health calls for policy level interventions to reduce the use of benzodiazepines, drugs commonly prescribed...

Benzodiazepine Use Linked to Dementia and Memory Loss

A recent review of the research found that benzodiazepine use may have long-term effects on memory and increase the risk for dementia. The study,...

SSRIs and Benzodiazepines Associated with Problems in Infants

Infants exposed to SSRIs and benzodiazepines during pregnancy show impaired neurologic functioning in the first month after birth, according to a new study published in the American Journal of Psychiatry. While infants exposed SSRIs alone showed neurobehavioral effects throughout the first month, those exposed to an SSRI and a benzodiazepine had more significant problems.

Still Mistreating the Elderly with Psychiatric Drugs: Benzodiazepines

Despite safety concerns, a new study reveals that there has been no change in the use of benzodiazepines in the elderly from 2001 to 2010.

Benzodiazepines Linked to Treatment Resistant Depression

Prior use of benzodiazepines, such as Xanax, Librium, or Ativan, may increase the risk of treatment-resistant depression (TRD), according to a new study published in The Journal of Nervous and Mental Disease.

Slew of New Studies Spot Links Between Psychiatric Medications and Bone Loss, Fractures

Four different studies conducted in different ways examining different groups have linked use of certain psychiatric drugs to bone fracture risks and negative impacts on human bone development.

Antidepressants Tied To Increased Risk of Homicide “Only Modestly”; Benzodiazepines More So

Taking antidepressant or benzodiazepine medications increases the risks that a person will commit a homicide, according to a study from Finland published in a World Psychiatry letter.

Valproate Linked to Decreased Brain Volume in Children Diagnosed with Bipolar Disorder

Researchers find that valproate decreases brain volume in a region associated with emotion processing across all participants.

Effort to Tackle Overuse of Antipsychotics in Older Adults Backfires

A partnership designed to decrease antipsychotic use in elderly patients may have led to increased use of medications with even worse risk/benefit profiles.

Anticholinergic Medications Linked to Dementia Similar to Early Alzheimer’s

A new study, published in the Journal of Clinical Psychiatry, investigates the effects of anticholinergic medications, such as antidepressants and antipsychotics, on cognition in older adults diagnosed with schizophrenia.

Anticonvulsant Implicated in Birth Defects in up to 4,100 Children, French Study Finds

Between 2,150 and 4,100 children suffered from severe malformations connected to valproate prescription.

Withdrawal from Mood Stabilizers

A review of the scientific literature for withdrawal from mood stabilizers: mechanism of action, animal studies, withdrawal symptoms, discontinuation success rates, and relapse rates related to tapering speeds.

Infants Exposed to Psychotropic Drugs During Pregnancy At Risk

New research published in the July issue of The Journal of Clinical Psychiatry found that the use of mood stabilizers, antipsychotics, antidepressants, and hypnotics during pregnancy is associated with increased health risks to the infant.

Drug Treatment for Borderline Personality Disorder Not Supported By Evidence

New research published in the August issue of Psychiatric Annals evaluates the results of randomized control trials on the use of various psychotropic drugs for patients diagnosed with borderline personality disorder (BPD). Despite the “American Psychiatric Association’s practice guidelines endorsement of SSRIs as first-line therapies for BPD,” the results of the meta-analysis reveal that pharmacotherapy in BPD is “not supported by the current literature,” and “should be avoided whenever possible.”

Psychotropics Linked to Worse Physical Problems and Mortality in Psychiatric Patients

Common psychotropic medications may be contributing to the higher rates of physical illnesses and mortality in people diagnosed with mental illnesses.

Lithium May Cause Sexual Dysfunction — More Research Needed

Lithium appears to reduce libido and sexual function, and more research into the problem is needed.

Psychotropics During Pregnancy Raise Risk of Babies with Low Birth Weight, Hospitalizations

The use by mothers of any of four major classes of psychiatric medications during pregnancy significantly raises the risk that their babies will be born with low birth weights and will need to be hospitalized.

Long-term Use of Lithium Can Cause Kidney Failure

A third of patients who have taken the common psychiatric medication lithium for over ten years have developed "chronic renal failure" from the drug.

Assessing Increased Mortality Risks of Antipsychotics and Mood Stabilizers in Dementia

An article in January's American Journal of Psychiatry weighs the relative risk of mortality associated with various antipsychotics and mood stabilizers used in the treatment of...

Medications May Add to Mortality Rate in Schizophrenia

Dutch researchers write in the Journal of Clinical Psychopharmacology that, in a prospective study of 7415 persons with diagnoses of schizophrenia, use of a first-generation...

Increasing Numbers of Children Prescribed Multiple Psychiatric Medications

According to researchers, children are being increasingly prescribed multiple different psychiatric medications.

Teacher Perspectives on Student ADHD Medication Use

Qualitative study examines patterns in teacher attitudes and knowledge related to medication of students for ADHD-type behaviors.

Children Taking ADHD Drugs More Likely to Take Antidepressants as Teens

Adhering to a commonly prescribed medication for ADHD in children is associated with higher chances of being prescribed antidepressants in adolescence.

Adderall Use Associated with Increased Risk of Psychosis

Twice as many teenagers with ADHD experienced severe psychosis when taking Adderall, as compared to Ritalin, according to a new study.

About 1 in 100 Children Treated with Ritalin Experience a Serious Adverse Event

A recent Cochrane review has found that serious adverse events occur for about 1% of children and adolescents treated with Ritalin.

Rates of ADHD Diagnosis and Prescription of Stimulants Continue to Rise

Two new articles find that rates of ADHD diagnosis and stimulant prescription continue to rise all over the world.

Hallucinations Reported as Side Effect of ADHD Medication

Hallucinations and other psychotic symptoms have been reported after methylphenidate (Ritalin) treatment for ADHD.

Large Increase in Poison Control Calls for Children Taking ADHD Drugs

New data shows that calls to US poison control centers have increased significantly for children taking stimulant ADHD drugs.

Stimulant Drugs Have Adverse Effects on Cognitive Functioning in Healthy Students

Study of students without an ADHD diagnosis finds that stimulants (Adderall) have little impact on cognitive performance.

Despite the Evidence, Overprescription of Stimulants Continues

A new study finds that stimulant prescribing rates to children continue to rise despite the well-established evidence documenting overdiagnosis of ADHD and overprescription of stimulants.

Race and Class Affect Teacher Perceptions of ADHD Medication Use

Study uncovers teachers’ attitudes surrounding ADHD medication use and examines the influence of race and social class on teacher beliefs.

CDC Reports Increased Psychostimulant Prescriptions in Women of Reproductive Age

Psychostimulant prescriptions have increased by 344% (from 2003 to 2015) for women of reproductive age (15-44 years old).

Children Diagnosed with ADHD Younger are More Likely to get Multiple Medications

New research demonstrates that children diagnosed with ADHD at younger ages are more likely than those diagnosed later to receive multiple medications within five years of their diagnosis.

Stimulant Medication Use Linked to Sharp Increase in BMI by Eighth Grade

New evidence suggests that children on ADHD medication may have stunted growth initially but more rapid increases in body mass over time.

African American and Hispanic Youth Discontinue ADHD Treatment at Higher Rates than White Youth

Study examines racial and ethnic disparities in the quality of care for Medicaid-enrolled children starting ADHD medication.

Lancet Psychiatry Needs to Retract the ADHD-Enigma Study

Lancet Psychiatry, a UK-based medical journal, recently published a study that concluded brain scans showed that individuals diagnosed with ADHD had smaller brains. That conclusion is belied by the study data. The journal needs to retract this study. UPDATE: Lancet Psychiatry (online) has published letters critical of the study, and the authors' response, and a correction.

Long-term Usage of ADHD Drugs Linked to Growth Suppression

Findings suggest that treatment not only fails to reduce the severity of “ADHD” symptoms in adulthood but is associated with decreased height.

Withdrawal from ADHD Medications

This guide to the scientific literature on withdrawal from ADHD drugs provides a review of animal studies, withdrawal syndromes, and possible tapering protocols.

The ADHD Drug Epidemic: Addiction, Abuse, and Death

A new analysis of FDA data, published on September 10th by the Milwaukee Journal Sentinel/MedPage Today, reveals the dangers of the common prescription of...

Study Finds ADHD Drugs Alter Developing Brain

A new study, published in the JAMA Psychiatry, investigates the effect of stimulant ‘ADHD’ drugs on the brains of children and young adults. The...

New FDA Study Shows Benzodiazepines Can Cause Long-Term Injury

The FDA has finally acknowledged the adverse effects of benzodiazepines, the dangers of withdrawal, and that the current packaging does not sufficiently warn of these harms.

Surviving Antidepressants: An Interview with Adele Framer

That is the truth about withdrawal syndrome: It’s like a 50-50 chance that you’re going to have a problem. If you’re in the unlucky half, you’re gonna be really unlucky.

Psychiatry’s Top Experts Acknowledge Lasting Harms of Antidepressant Withdrawal

Royal College of Psychiatrists’ former president demands support for patients coming off antidepressants.

Tapering Strips Help People Stop Using Antidepressants, Study Finds

A new study by Peter Groot and Jim van Os investigated whether tapering strips can help people stop using antidepressants.

Very Slow Taper Best for Antipsychotic Discontinuation

An article in JAMA Psychiatry advises very slow tapering for best results when discontinuing antipsychotic drugs.

Strategies for Tapering and Discontinuing Antidepressants

A new review of strategies to support both patients and practitioners through the process of discontinuing antidepressants.

Service-User Knowledge Helps Researchers Develop Psychiatric Drug Tapering Approaches

New strategies for tapering psychiatric drugs achieved by acknowledging withdrawal symptoms and valuing service-users’ first-hand knowledge.

Review Documents Severe Withdrawal Effects of Psychiatric Drugs

Researchers find that most psychiatric drugs cause severe withdrawal despite attempt s to gradually decrease the dosage.

Neuropsychological Tests Reveal Consequences of Polypharmacy

Neuropsychological assessments reveal the cognitive, occupational, and social impact of polypharmacy in psychiatry.

Researchers: Antidepressant Withdrawal, Not “Discontinuation Syndrome”

Researchers suggest that the pharmaceutical industry had a vested interest in using the term “discontinuation” in order to hide the severity of physical dependence and withdrawal reactions many people experience from antidepressants.

Prescribing an Epidemic: A Veteran’s Story

Had I known what I know now, I never would have taken any of these drugs, and I absolutely would not have taken a role in which my outreach efforts to get veterans into mental health treatment might place thousands of lives at risk.

Medication-Free Treatment in Norway: A Private Hospital Takes Center Stage

At the Hurdalsjøen Recovery Center in Norway, patients with a long history of psychiatric hospitalizations are tapering from their medications and, in a therapeutic environment that emphasizes a good diet, exercise, and asking patients "what do they want in life," are leaving their old lives as chronic patients behind.

Fear and Belief in “Chemical Imbalance” Prevent People from Coming Off Antidepressants

Researchers interviewed people who were given medical advice to discontinue antidepressants.

NICE Guideline Update Acknowledges Severe Antidepressant Withdrawal

A new update to the NICE guideline for depression suggests providers discuss long-term, severe antidepressant withdrawal symptoms.
sertraline antidepressant withdrawal

Ambushed by Antidepressant Withdrawal: The Escape Story

I’m alive. More than 30,000 veterans in the past decade alone are not. I was not warned of the risks of this drug. I was not told that once on it, I might never be able to get off it, or the nightmare that would ensue when I tried. I know millions of others were not told either.
A box of Zyprexa pills.

Lack of Clear Guidelines Prevent Clinicians from Reducing Antipsychotics

A recently published study from noted critical psychiatry expert Joanna Moncrieff explored the barriers that prevent clinicians from helping service users in discontinuing or...
the new yorker

The New Yorker Peers into the Psychiatric Abyss… And Loses Its Nerve

The New Yorker's story on Laura Delano and psychiatric drug withdrawal is a glass-half-full story: It addresses a problem in psychiatry and yet hides the deeper story to be told. A story of how her recovery resulted from seeing herself within a counter-narrative that tells of the harm that psychiatry can do.

More Psychological Supports Needed to Manage Antidepressant Discontinuation

Study reviews psychological interventions for antidepressant discontinuation.

Withdrawal Symptoms Routinely Confound Findings of Psychiatric Drug Studies

Researchers examine how rapid discontinuation can mimic the relapse of mental health symptoms and confound psychiatric drug studies.

Peer-Support Groups Were Right, Guidelines Were Wrong: Dr. Mark Horowitz on Tapering Off Antidepressants

In an interview with MIA, Dr. Horowitz discusses his recent article on why tapering off antidepressants can take months or even years.

Suicide in the Age of Prozac

During the past twenty years, the American Foundation for Suicide Prevention and American psychiatry have adopted a "medicalized" approach to preventing suicide, claiming that antidepressants are protective against suicide. Yet, the suicide rate in the United States has increased 30% since 2000, a time of rising usage of antidepressants. A review of studies of the effects of mental health treatment and antidepressants on suicide reveals why this medicalized approach has not only failed, but pushed suicide rates higher.
antidepressants

Do Antidepressants Work? A People’s Review of the Evidence

After a meta-analysis of RCTs of antidepressants was published in Lancet, psychiatry stated that it proved that "antidepressants" work. However, effectiveness studies of real-world patients reveal the opposite: the medications increase the likelihood that patients will become chronically depressed, and disabled by the disorder.

Psychiatry Defends Its Antipsychotics: A Case Study of Institutional Corruption

Jeffrey LIeberman and colleagues have published a paper in the American Journal of Psychiatry stating that there is no evidence that psychiatric drugs cause long-term harm, and that the evidence shows that these drugs provide a great benefit to patients. A close examination of their review reveals that it is a classic example of institutional corruption, which was meant to protect guild interests.
rxisk

Rxisk maintains a searchable database of adverse effects of prescription drugs that have been reported to the FDA in the United States, Health Canada, and to RxISK.