New guidance for primary care doctors in the UK on antidepressant discontinuation acknowledges severe and long-lasting withdrawal symptoms.

Post-SSRI sexual dysfunction (PSSD) may be a common adverse effect of antidepressants. Researchers are now attempting to understand the neurobiology behind it.

A new study promotes the use of a standardized approach to antidepressant tapering.

Combining drugs and therapy also did not lead to better depression outcomes than therapy alone.

Leading ADHD researchers outline four mistakes that turned ADHD from a description of behavior into a medical disease.

Also, male mice born to mothers with an immune response exhibited “autistic-like” behaviors, scientists report.

Paroxetine, SNRIs, and MAOIs were associated with the highest risk of withdrawal, as was long duration of use and whether the person experienced withdrawal in the past.

A new study in rats found that those exposed to antidepressants in utero had an impaired ability to nurture their own children in later life.

Adults receiving ADHD medications and therapy frequently experience adverse events that interfere with employment and daily life.

A new literature review reinforces the need to “down-titrate” or taper antidepressants, especially drugs like Celexa and Paxil.

New evidence suggests that lithium, commonly prescribed for bipolar disorder, can increase the risk of chronic kidney disease.

Researchers suggest that antidepressant withdrawal can be a possible precipitant of suicide.

A study finds that commonly prescribed antidepressants are associated with the development of diabetes, hypertension, and other diseases.

Babies born to mothers taking antidepressants during pregnancy were more than six times as likely to have neonatal withdrawal syndrome—including breathing problems, irritability/agitation, tremors, feeding problems, and seizures—than those born to mothers taking other types of drugs.

Researchers can’t predict the 15% who benefit from antidepressants, and the other 85% are unnecessarily exposed to the harms of the drugs.

In a real-world setting, less than a quarter of patients diagnosed with depression improved with medication, hospitalization, and therapy.

Nassir Ghaemi: “Most psychiatric medications are purely symptomatic, with no known or proven effect on the underlying disease. They are like 50 variations of aspirin, used for fever or headache, rather than drugs that treat the causes of fever or headache.”

Researchers found that 25% of elderly patients taking antidepressants had serotonin syndrome, which is potentially life-threatening.

Researchers highlight how systematic reviews are compromised by pharmaceutical industry ties by exposing a study of injectable antipsychotics.

“Efforts to improve learning in children with ADHD should focus on obtaining effective academic instruction rather than stimulant medication.”