Antidepressants always made me feel wired. I thought antidepressants would un-depress you and create relaxation, but they are hard to be on. It looks like I never needed more serotonin and certainly not the extra cortisol that antidepressants release. Antidepressants are stimulating and uncomfortable to be on. They affect sleep, yet I would have thought that good sleep would be vital for overcoming depression.