Tuesday, January 22, 2019

Comments by sanneman

Showing 3 of 3 comments.

  • Hi Steve,

    Thanks for your comment. Although we were as thoughtful as possible choosing our vocabulary, I have to admit that in retrospect I’m not too thrilled by words like ‘medicine’ and ‘diagnosis’ either. Although I’m sure that some keyfigures in the ADHD-community have willfully introduced some rhetoric elements into the discourse, I think most of such reifying language has become a bad habit that most of ‘us’ are not aware of and that’s hard to break, so thanks for keeping us sharp.

    Having said that, I also want to distance myself from words like ‘fraud’. Although I find myself angry at times with the state of affairs as they are (and I might even have been judgmental about Allen Frances when I met him) I think such words have a tendency to polarise, creating a dichotomy where we should be seeing the different shades (even if they seem grey). I think for instance the DSM-IV-TR guidebook is quite thoughtful on ‘ontological issues’ and dimensionality of behaviour.

    Despite unholy forces from the overly liberalized healthcare market –particularly in the US, I think most psychiatrist like Allen Frances have good intentions, and we have not intended to suggest ADHD is a fraud. Some children are really difficult to deal with, even if it is just their temperament in most ‘cases’ that has spiralled into problems in interaction with overworked parents, stressed out teachers in overcrowded classrooms, off-the-scale divorce rates and other sociological issues.

    However, yet another possibilty–in line with the biopsychosocial model Allen Frances proposes on the video of the MIA homepage- is that the heterogenous group of those being diagnosed might also be populated by some FAS children. These are notoriously hard to distinguish from children who have attentional problems for other reasons. I feel this could even explain some of the small, average, group differences in anatomical studies looking at brain size. I do not want to suggest they should be treated with drugs (they’ve had their share I’d say) but it does suggest that we should really keep communicating with biologically oriented professionals and avoid going from a biological narrative straight into an exclusively psychosocial one. Although for this small subgroup of children I’d say the social adversity and low SES related to drug abuse should be our first concern –as is often the case.

    Kind regards, Sanne te Meerman

  • Dear Robert,

    With regard to your stance on the ‘smaller-is-not-a-dysfunction point’: that is an interesting angle. My perspective was that not mentioning this would leave the option open that those diagnosed that do have smaller brains indeed have a verified brain disorder. With regard to the IQ argument: I think this is also a very interesting point. Seems very plausible that some in the heterogeneous group diagnosed with ADHD indeed are simply bored and unruly because of this, although I would not expect all that much from this -the IQ scores are merely averages as well-. Many diagnosed will probably have IQs as the rest the of us mortals – they’re almost normal humans :-). However, I personally do not feel that leaving the IQ scores out attests to a lack of ethics as it wasn’t the research question of the authors. Although we were not aware of this -we didn’t see the appendix- it would not have been our central argument I think. It is great that you retrieved this additional info though as it is indeed an interesting finding in itself. Thank you for this thoughtful petition, I hope my thoughts help to sharpen your thoughts even further.

  • With several scientists from the Netherlands I have written a response to The Lancet Psychiatry, due for publishing June, 2017. Our criticism is mostly centred around the overlap between the research groups, mentioned here as well. The authors of this petition add some great points to this. However, I do concur with Kjetil Mellingen who comments on some important missing things, like the correlation-causation error, and the fact that brain size differences do not necessarily implicate dysfunction. Additionally, the fact that brain size catches up later in life –and growth is another bell-curved variable in which people vary- is an extra argument that emphasizes that brain size does not equal illness or disorder. In my view these points could have replaced some of the weaker arguments of the petition.

    Personally, I think a little too much has been made of the apparent error in the paper with regard to the confidence interval of the Accumbens. As figure 1 of the paper shows, this is a typo (the figure indicates that the authors have meant -0.10). Additionally, I do not think the fact that several sites that provided data for the study show different, sometimes even bigger, brain parts should be an argument for retraction necessarily. Increasing power by adding sometimes conflicting findings seems one of the points for doing a meta-analysis. Also, the fact that not all controls were healthy does not seem like a strong argument. Arguably, the common use of well-controls is more problematic as they are not representative of ‘normal’ people and thus impede generalizability.

    However, the far-fetched conclusion of the research article not justified by the data is sufficient reason for retraction and the editors of the Lancet Psychiatry should have prevented such clear logical and scientific fallacies from being published. The unreliability of the results and the resulting validity problems the authors of the petition expose in addition to this are additional strong arguments why these far-fetched conclusions should not have been published.