The authors compare benzos to TCA’s not really a fair comparison as TCA’s are not routinely used for depression or anxiety much today. As a pharmacist working specifically in mental health who does not like to take medications in my own personal life (and advocate for stopping useless medications for patients I serve) I often am straddling the fence between rhetoric of Pharma and blogs such as this. As best I can my goal is to provide education on risk and benefit and let individuals make their own mind. My issue with many of the posts on this blog and others is the continued argument that the public is being fooled by this or that study to use a group of medication (over a cheaper alternative) for financial gain of pharmaceutical company. However not a single SSRI is still under patent of big Pharma. Venalafaxine, mirtazapine and bupropion (other 2nd gen antidepressants) are also all generically available for mere cents per tablet. Out of the 4 branded antidepressants available, only Cymbalta is one that I see being used with any frequency. Benzodiazepines are not all bad but come on the withdrawal between a benzo and antidepressant are not even close in safety, less we forget of fatalities from benzo withdrawal. Also withdrawal does not equate to abuse or drug seeking behavior, the later of which SSRIs does not cause. Nor the same level of toxicity when combined with alcohol, opioids or even alone.