My guess is that Mark is not talking about untreated psychosis being physically damaging to the brain. The damage in that situation may refer to damage regarding other areas in the persons life such as loss of relationships, financial, and possibly traumatic experiences that may come during that period the person is going through that period. It is not a damage that can be scientifically quantified. I think that there is probably a pretty unanimous agreement with people interested in mental health that it is not good for a person to experience a prolonged state of distress and anguish. (that is a key part of much of these models being looked at as effective treatments that do not have a minimal medical component). They use a quick response when the person begins to experience concern. It is an extreme example but take for instance a man that has been homeless for 10 plus years and has non treated mental health issues. Has a lot of apparent distress yet has difficulty focusing due to hearing voices and has difficulty organizing his thoughts. He is open to meeting with people and discussing issues in his life but there is a lot of difficulty with getting very far in conversation. It would be apparent that this person receiving no treatment has been damaging in his life. If he is interested in possibly taking a medication to see if he receives any benefit from it would be a pretty clear cut good use of trying a psych med. Is this going to improve his life very much maybe and maybe not. And of course there are million different ways that this persons life could go after trying or not trying a medication as each person is different and there are many factors both positive and negative beyond what he has been prescribed. I can easily think of times where I have seen where medications have been damaging to a persons life while at the same time can think of where it has been a part of a spectrum of other “interventions, treatments, what ever you want to call it” that have led to a positive change in a persons life. I think when ideas such as all psychiatric medications should be done away with as they are damaging, it negates a lot of peoples experience out there. (you can say that their perception has been blinded by propaganda and being told, but whose perception isn’t shaped by these factors)There are a lot people that report positive benefits in their lives from taking or having taken meds in the past. What would there lives have been with or without having taken the meds? Does the benefit that they see from taking the med(s) out way the harm? Hard to say as each person is different and there are factors in each persons life that can not be measured in a study. Therefore knowing that there is damage caused by taking medications however if there are going to be medications prescribed it would be great to know that the Dr. you are sitting across from actually takes this into account along with may other factors occurring in your life and is wanting to come up with the least damaging with the most beneficial outcome.