As you mentioned, they used response rates, not absolute changes in score per se. If it’s more likely that with the drug you end up getting >50% decrease on your Hamilton score it really doesn’t matter if on placebo there’s just simply more people that get for instance 48% or 49% decrease. So this methodology just fades out the fact that the decrease on Hamilton score compared to placebo is not clinically relevant and which I think more important, not patients own evaluation. However, what I find more interesting is that the study revealed that there was usage of benzodiazepine in 36% of the clinical trials (for adverse reactions?) The researchers also mention: “We also observed that drugs tended to show a better efficacy profile when they were novel and used as experimental treatments than when they had become old.” That tells you something.