Saturday, December 3, 2022

Comments by thomas Schnell

Showing 21 of 21 comments.

  • The brain is so complex it is bound to fail. It should have many “pieces” that are in low supply or do not function as designed. A brain is a part of human anatomy and we are prone to breaks and sprains and wearing out. It is the seat of thinking and feeling and it can become diseased. With hundreds of billions of connections through synapses our neurons can’t possibly function perfectly all of the time. If I cut off my foot, I can still think and feel and function. If I cut off my brain, that’s it.

  • I appreciate your respectful approach. I wouldn’t make it as a hunter, either. I like the consideration given to us, a way of defining our differences that isn’t insulting and instead relies on evolutionary forces to explain our brief attention spans. Back in the day we made a positive impact on society because of our ADHD-like abilities to pay attention to the slightest movement or sound, too restless not to be hunters, thriving on the rush of hunting wild animals.
    And, indeed, stimulants help almost everyone to pay attention better. We are merely a cross section of society who function at a level so far below our potential, that we are unable to master life in a meaningful way.
    I can’t follow along during a lecture, no matter what I do, including consuming dozens of cups of coffee or smoking nicotine or chewing it, or working out aerobically. Novelty helps and being fascinated by a topic can help briefly. However, if I take my rx as prescribed, I experience a miracle (with tears in my eyes I tell you this.) I had no idea I couldn’t or wasn’t paying attention. I couldn’t figure out how others knew what to do, what was spoken or read. I was a lazy G D. S.O.B. is all. I was told that so often I believed it and the only way to prove I wasn’t “no good” was to improve at my schoolwork. Since I couldn’t do that, I hated myself as much as I could, hoping that if I detested myself sufficiently (by believing what I was told) I would find the motivation to improve. But, I couldn’t even hate myself as much as I should have, or I would have changed. So, I just kept trying to hate myself as much as I deserved. Then, one day, I was given “a new pair of glasses.” I could see and hear and follow along, do Algebra II, write, follow instructions. I was in heaven. I was alive. My past was not the result of defiance, being a spoiled punk, a jerk, a useless bum. That wasn’t me. I wanted to learn my entire life. I was fascinated by this incredible world (still am) and it broke me not to be able to demonstrate that to my parents. I longed, I ached for my dad to know that I wasn’t “no good.” No one knew my heart.
    A “new pair of glasses” has completely revolutionized my life.

  • Donation data reported on websites by drug makers and patient advocacy groups in Canada that receive industry funding is “haphazard, inconsistent and incomplete,” underscoring the difficulties in deciphering the influence these companies may have on patient interests, a new analysis finds.

    Specifically, information about the value of donations made by drug companies, the years in which contributions were given, and the percent of income the money represented for patient groups was limited. Consequently, donations made and received often could not be matched, according to the analysis in the International Journal of Health Policy and Management.

    ED SILVERMAN PHARMALOT

    Seems as if there is disagreement about these matters.

  • Conclusions: Our results establish a dose-dependent binding effect for viloxazine at the 5-HT2C receptor in the choroid plexus. The 60% displacement of the radioligand by viloxazine at a clinically relevant dose (3 mg/kg) may be attributable to direct occupancy of the 5-HT2C receptor by viloxazine. In the cortical regions, a dose-dependent displacement of [11C]CIMBI-36 by viloxazine was also seen. The effect of viloxazine in the cortical regions (rich in 5-HT2A receptors) may be attributable to either direct occupancy of 5-HT2A or due to increased release of synaptic 5-HT. An estimated EC50 value of viloxazine for the changes in BPND at the 5-H2A receptor is significantly higher than the unbound plasma concentrations of viloxazine at all doses tested. This suggests that the observed effect on radioligand binding may result from a viloxazine-mediated increase in endogenous 5-HT release rather than direct binding to the 5-HT2A receptor in the cortex. Overall, our experiments suggest that, at clinically relevant doses, viloxazine increases serotonergic neurotransmission in the PFC and acts on the 5-HT2C receptor, which could play a role in its efficacy in the treatment of ADHD.

    NATURE Great news as science moves ahead to uncover the mysteries of the ways our brains work and fail to work.

  • Dr David Curtis, Honorary Professor at the University College London Genetics Institute, who told the Science Media Centre:

    “This paper does not present any new findings but just reports results which have been published elsewhere and it is certainly not news that depression is not caused by ‘low serotonin levels’. The notion of depression being due to a ‘chemical imbalance’ is outmoded, and the Royal College of Psychiatrists wrote that this was an over-simplification in a position statement published in 2019.

    “Nor is it the case that SSRI antidepressants increase serotonin levels. Their immediate action is to alter the balance between serotonin concentrations inside and outside neurons but their antidepressant effect is likely due to more complex changes in neuronal functioning which occur later as a consequence of this.”

    And here’s another one from Vidita Vaidya, a neurobiologist at the Tata Institute of Fundamental Research, Mumbai, who has worked extensively on the role of serotonin and SSRIs in the neurobiology of emotion:

    She pointed to one hypothesis that purports to explain, for example, the antidepressant effect of SSRIs….

    “Serotonin is a regulator of plasticity in the brain,” Vaidya explained – suggesting that SSRIs could lead to changes in neuroplasticity, which in turn alleviates depressive symptoms in ways that are not clearly understood. This is the neuroplasticity hypothesis.

    This neuroplasticity hypothesis is important to note. It’s another well-known and accepted hypothesis in the psychiatric community of how antidepressants might work other than the low serotonin hypothesis.

    Wait, one last one to really drive home the point here:

    David Hellerstein, professor of clinical psychiatry at Columbia University Medical Center and director of Columbia’s Depression Evaluation Service, explains that the serotonin hypothesis — i.e., the idea that depression is caused by low serotonin levels — is a “quaint and oversimplified shorthand that has been superseded by other explanations in clinical practice for a decade or more.”

    He says that the review was largely met with yawns from the psychiatric community. “In reading it, I was kinda thinking, ‘Wow, next she’ll tackle the discrediting of the black bile theory of depression,” he tells Rolling Stone.

    Several U.K. researchers and psychiatrists, as well as a spokesperson for the Royal College of Psychiatry, criticized the paper, questioning why an umbrella review of outdated studies was even needed. That prompted Moncrieff and her co-author to issue a rebuttal.

  • I don’t think most therapists want to classify those seeking their help in any particular fashion before they have taken the time to get to know the individual, unless their issues are glaring. “Figures never lie, but liars often figure.” I think we can misinterpret a great deal of data depending on are own psychological make-up.
    I think self-pity can keep us stuck, spinning our wheels, and be unaware of it.

  • According to the new study, that gene may just be CDH2, should that gene mutate.

    CDH2 is a gene that encodes N-cadherin, which is responsible for helping in brain synapse activity and formation. A mutation in CDH2, however, alters this activity. This, in turn, impacts molecular pathways and dopamine levels in two specific brain structures: the ventral midbrain and the prefrontal cortex, both of which are involved in ADHD.

    Further studies have been initiated by the Birk team at BGU’s National Institute for Biotechnology in the Negev (NIBN).

    ADHD is complex and researchers are beginning to zero in on the areas of the brain most responsible for the condition. There is a consensus that the symptoms are real and they can and do cause great injury.

  • William Griffith Wilson (1895-1971)

    Prior to founding AA, Wilson was an extreme alcoholic, and was admitted to the hospital several times for it. He wrote of it like this:
    “My depression deepened unbearably and finally it seemed to me as though I were at the bottom of the pit. I still gagged badly on the notion of a Power greater than myself, but finally, just for the moment, the last vestige of my proud obstinacy was crushed. All at once I found myself crying out, “If there is a God, let Him show Himself! I am ready to do anything, anything!”

    Suddenly the room lit up with a great white light. I was caught up into an ecstasy which there are no words to describe. It seemed to me, in the mind’s eye, that I was on a mountain and that a wind not of air but of spirit was blowing. And then it burst upon me that I was a free man. Slowly the ecstasy subsided. I lay on the bed, but now for a time I was in another world, a new world of consciousness. All about me and through me there was a wonderful feeling of Presence, and I thought to myself, “So this is the God of the preachers!” A great peace stole over me and I thought, “No matter how wrong things seem to be, they are still all right. Things are all right with God and His world.”

    (Source: Alcoholics Anonymous World Services. 1957. Alcoholics Anonymous comes of age: a brief history. New York: Alcoholics Anonymous World Services, 64.)

    This experience had a tremendous influence on Wilson. After a seven day stay in the hospital he never drank again for the remainder of his life. He and Dr. Bob Smith, another hopeless alcoholic, began one of the greatest spiritual movements in the world. It sprang up mostly in the homes of drunks and in the basements of churches without leaders or finances, without promotions or earthy structure and guidance. Wouldn’t you know, God was found in places where no one was looking for him.

    He said his “awakening” was available to all.

  • You pointed out that you interviewed kids and how their reaction to stimulants might surprise me. I know people respond differently. Not my point. Your interviews were not broadcast or transmitted on major media outlets or written down word for word and published in TIME or NEWSWEEK or the NYTs. The Big Media has never reported the breakthrough accounts so common among us.
    As far as the Media is concerned, we don’t exist and that is a tragic, deliberate and an unfair miscategorization of adults and kids with ADHD. Deception through silence.
    You continue to make the point that not everyone has the same outcome. I am aware of that. My point is that we do not hear about the success stories. My point is, the Big Media doesn’t run genuine human interest stories regarding the nearly miraculous results many of us experience. That is my point. No one in the Big Media wants to hear from us. We’ve been to hell and remained there a long time. We came through it and to me that is something worth reporting on.

  • I think it would be helpful for everyone if people would make a concerted effort to listen to those who have ADHD and are wearing “a new pair glasses” that make all the difference. I have never seen one person who has come through battling ADHD interviewed by an impartial journalist or anyone else. Not one time. We have something to say and we are ignored. Experts and pundits voice their opinions everywhere even as we are left out in the cold. No one says to us, “Tell us what happened to you. Tell us your story. What was it like having to deal with this misunderstood, damnable disorder all your life? What is it like now that you can pay attention? How does it feel?” We can shed light on the topic and people might learn a thing or three from us. What would it hurt to give us a voice?

  • Very well written. I disagree with the rounded off conclusions in some ways. We have invested far more money, time and the expertise of researchers/scientists into understanding and successfully treating cancer, and while we have made a lot of progress, we have a long way to go. Yet, we have no thought of giving up the quest to eradicate it and the damage it causes. The biomarkers may be weak or minor contributors that cause ADHD, but right now we now use the most sophisticated medical equipment ever developed and we are teasing out the microscopic weaknesses, defects, and the dysfunctions within and among neurons. It is a fascinating time to be hangin out. Remember, too, we can’t cure the common cold and we know colds are real.
    Stimulants help the majority of those with this disorder. I assure you from my experience as one who has used them for decaders, they work. I could never write what I just have, without the focusing benefit they yield. Years ago I was given an Rx for a new pair of glasses. Tragically, for most of my life, I only caught glimpses of life as it is. Thankfully, due to my new pair of glasses, vistas I never dreamed of have opened up before me. I participate in all of life.
    Reminds me of an ancient biblical story in which a man born blind bumps into this carpenter who gives him sight. Some accuse him of being healed by some crackpot. I don’t know about that, he says. All I can tell you is, I was blind but no longer.
    This QB for New England, Josh Allen, is the real deal and he is exceptional. I hope he can stay healthy.

  • No one recognised the trauma I faced daily in school, home and everywhere else. I couldn’t follow along. I heard bits and pieces of some sentences. I learned to endure hours of sitting in a classroom having no idea what was taught. I endured agony as my parents condemned me for being a lazy G. D. bum. I couldn’t read past the third grade level. My mother came to class and sat next to me all day to try to figure out why I wouldn’t apply myself. She reminded me many times to pay attention, which I would do, for about 2 seconds. No one was there for me, to be a source of comfort as I lived in hell day after day, blaming myself, hating myself, despising myself for not doing what I was supposed to be doing. I had not the faintest idea, at all, that I wasn’t paying attention. I did believe strongly, deep down, if I could hate myself enough, as I deserved to be hated, I would be able to pull through all the disgraceful things I was and I was doing, and become a good student.
    One loving, accepting, warm-hearted adult present in my life over those years would have saved me from the harshest side of imprisonment in a concentration camp by myself–without family.
    One mom or dad-like figure who said, “It’s okay. You are a good boy. You are a wonderful little boy” would have eased the pain.