Comments by David Smith MD

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  • You criticize the studies as being too small, or biased and then you do the unthinkable. You use studies for Esketamine to draw conclusions about IV ketamine. I would agree that Esketamine is ineffective, however it is a single isomer given intranasally. Providers like myself use a racemic mixture of ketamine given over a specified time period. Anyone with sense knows that the comparison of those 2 different drugs is ridiculous. That in itself makes the entire article bogus.