Very interesting exchange. I’d say Allen Frances can’t entirely keep his mask on. His drug salesman face is peeking out from behind his physician mask. Same physician mask expressing remorse for his part in the DSM-IV fiasco. Despite all his talk about reducing doses, aggression cannot be attributed, by him anyway, to SSRI anti-depressants, and this, to my way of thinking, greatly reduces the impact of his argument, especially when 10 % of the population at home and abroad are on these drugs. He worries about physicians not providing “needed” drugs. Come, come. With 10 % of the population on them, surely, Dr. Frances, you jest. When all is said and done, I kinda think you’ve got another one here more concerned about the wealth in his wallet than the health of his patients.