Saturday, November 27, 2021

Comments by djpurity666

Showing 13 of 16 comments. Show all.

  • Thank you for writing this. It is exactly what I have been dealing with and realizing myself.

    As a diagnosed schizoaffective person, I spent years in some psychosis never hearing voices I believed to be my own thoughts but from other people and entities speaking to me.

    Over the past year my delusions began to slip away as well as most all of my symptoms except hearing voices.

    Those voices never told me to harm myself but would take up a lot of my time stuck in my head conversing with them.

    Eventually they did attack me, and I lashed out, wanting to hit them and scream. I got so desperate I tried a newer antipsychotic for a short time. Eventually they went away but mostly they got quiet when I quit the stupid medication.

    Since then I have gone thru many changes. I thought I was just hearing my own thoughts but in different vocal voices. Usually they are the same voices cycled over and over and I would eventually accidentally personify each one.

    I have learned that these really are not good coping mechanisms… These are NOT my own thoughts. I shouldn’t be responding to them. They aren’t real!

    It’s like my thought processes became fragmented, and I guess at times they served purposes and were mostly good. My brain has been trained to reward itself for having my thinking so fragmented. It made me rethink how dopamine is linked to the reward system and how many antipsychotic meds target dopamine.

    I am trying very hard to retrain my brain to stop responding to these delusional hallucinations. It isn’t easy to just stop overnight!! But I know this isn’t normal to keep accepting them as just my thoughts being heard like that.

    It really is about stopping the reward process on my own and ignore these things bc they aren’t real.

    I am beginning to see that each time I thought I was in remission of all symptoms, these voices would come back.

    But it’s great to read how others also reject their diagnoses and deal with healing on their own.

    I wish you and your daughter the best.

  • Everyone is so vastly different than you, their needs cannot be solved by a single amino acid with a bunch of things like B-vitamins. And then sent on their way totally coherent?

    Some people here are going off on tangents that have absolutely nothing to do with esketamine and how it actually functions in the brain or why it is even being studied in clinical trials and being approved.

  • Oh please. I was given ketamine in the hospital due to opioids failing to be able to control or handle the insane amount of pain and horror I was in at the time. And yes, I had been given things like fentanyl before, which has had a huge history of being a very helpful substance for people with severe chronic pain issues (or even just post-surgery issues, as I myself have had a script for it before, legally, after botched surgery on my arm to repair a falsely made diagnosis), yet now it is being headlined as this massive killer of people, yet none of this fentanyl is coming from the hospitals. China and Mexico are hugely responsible for manufacturing it cheaply and without enough control that it gets diverted to the streets and misrepresented. But to say that because of this that fentanyl should just disappear is ludicrous! I mean, there goes all the epidurals for women giving birth! Yeah, that’s right, women get fentanyl injected into their epidural location for pain relief giving birth these days. It is a hugely controlled drug (C-II) and way different than esketamine (which is NOT ketamine). That’s just going completely on a tangent. And some people OD on codeine! I cannot even metabolize that stuff! People are so massively different in their medical needs that they assume the horror stories being replayed for attention-getting value are all true and would apply to them, too! You call it a horse tranquilizer yet say no thanks to it if you ever go to the ER or OR? How on earth would you know?

    Ketamine and PCP are not any closer than just being labeled as dissociatives as a drug classification. Well, so is DXM, an OTC cough suppressant. You may as well decline ever using that bc you may accidentally dissociate!

  • YES we know ketamine is used by veterinarians, yet we as humans also use it in hospitals and hospice on other humans. To just dismiss anything having any medical value just because there are people who have used it recreationally or abused it pretty much dismisses everything out there right off the bat. Just take nasal spray right out of the market then. May as well pull benadryl as well as cough medicine like DXM. Holy cow, has anyone ever thought that maybe some people are self medicating with a substance and are not just hopeless addicts. OMG, there has been a huge amount of morphine addicts mostly since the Civil War began sending veterans home with it. May as well just discount morphine and all opioids due to millions of persons of all ages using this drug type, too.

    Ketamine itself is indeed used in ERs and hospitals, and I myself have gotten it in the operating room of a hospital.

    Daniel does NOT seem to be of the “some drugs are good, so more drugs are better” category. He just was stating that it is stupid to stereotype a drug based on its history in recreational use and not focusing on its medicinal value. And ketamine and esketamine are not identical substances!

  • Anyone can become situationally depressed. Is esketamine designed for situational depression? No it is not. Are some people abused and traumatized by horrible experiences in life? Unfortunately, yes there are, and sometimes these people are never given a chance to develop normal coping mechanisms in life and develop major depressive disorders and suicidal ideation. These are not normal states of mind, and no, they are not biological in origin. This is not some virus that esketamine is meant to eliminate.

    Some people are in deep moral black holes and/or develop into broken human beings with such horrible depression that suicide seems an option to deal with it. Getting these people to just “snap out of it” and realize that they can just change their own mental states by relearning their cognitive behaviors and emotional responses to trauma and abuse is quite difficult. Some people truly cannot get out of bed, let alone have the desire to go to a mental hospital for help.

    I know psych meds are mostly neurotoxic things, but sometimes there are people who need a stepping stone or crutch to just be able to get out of bed or out of a bad situation so they can get into proper therapy and learn to make lifestyle changes and all that, which people normally do without medication.

    Unfortunately, we cannot speak on behalf of those that are slashing their wrists because of abuse, neglect, trauma, rape, loss, shame, and/or defeat (yet so many people seem to think they can bc of their affluence and privilege in life that leads to the condemnation of the mentally inferior by merely stating that “if only they thought better, their lives would magically heal and all mental illness just vanish”).

    For anyone to write a book about how mental health is not a medical issue is just profiting by stating the obvious. No kidding it isn’t about any sort of virus of depression, as no such thing exists. The people who esketamine is designed to help are truly those that have tried things before that failed them as well as those that need a little artificial boost to get going on making lifestyle changes, if that is even possible.

  • It isn’t designed as first line treatment for depression. Has anyone done any research before posting comments about this? No child is going to get some C-III substance nasal spray for their depression. It is meant for those that have tried other things and they have failed, as well as for people with suicidal ideation. It isn’t something being designed to be just given to kids for off label use. Those kinds of doctors who would do such a thing are the real problem here.

  • I have never in my life around this substance ever heard of anyone ever using it as an aphrodisiac or date rape drug. This isn’t GHB or rohypnol (GABA related inhibitory effects/modulation for the most part, not even close to NMDA antagonism).

    Do you really think esketamine will be prescribed in doses where people will be shoving it up other people’s noses to date rape them? That’s simply not how it functions.

  • I highly doubt this. This isn’t ketamine. This is esketamine, which has been researched to specifically target suicidal ideation and tendencies.

    If anyone would just read about the mechanisms of action and why the NMDA receptors are now the hot focus of new treatment lines (rather than just serotonin, norepinephrine, and dopamine), it would be an interesting discussion. All these anecdotal references to hearing about it in bars in other people’s conversations or believing that it is just a drug that just fucks people up (as you say) is just Cracker Jack box science, as someone basically has said.

    Can anyone bring any real neurobiology into this discussion rather than just fearmonger a drug that is actually a C-III substance in the USA (it isn’t C-II or C-I) that has been used effectively for many things that aren’t close to what people seem to think it does?

  • It’s not meant to be used as a tranquilizer for horses. It isn’t some animal painkiller alone. It’s been used in hospitals on human beings for quite some time now, everyone. And while some people who have used it recreationally may think it’s awesome and all that, it isn’t bc they are using a horse tranquilizer. Personally, all this talk about something no one here seems to have taken themselves just makes the whole topic just a bunch of opinions and anecdotal observations not even close to being accurate.

  • Ketamine infusion therapy (and ketamine nasal spray) has been in the United States for a while now for treating many things. Ketamine itself has been used in hospitals. I myself have gotten it in a hospital ER setting by anesthesiology. It works amazingly well for extreme pain that is resistant to opioids, and it is amazing for mood and other issues. Having in the hospital was not my first experience with ketamine either. I’ve taken it intranasally before with amazing results. It cured so many issues that I had no idea were such issues to me then. I have seen ketamine do amazing things in other people personally. Otherwise I wouldn’t share my own personal experience with it. It seems pointless to argue about anything’s effectiveness without having personal experience with it, in my opinion. Esp when one dose can last for so long or change a person’s life from dose #1.

    But to state that everyone absolutely will respond the exact same way also is a futile argument. Some people have gene mutations and enzyme variations among so many other physiological differences. Any variation in anything can result in totally different effects and complications. Just like any powerful dissociative analgesic that is also potent on the mind and spirit, it does come with the history of being diverted for nonprescription use by people of stereotyped backgrounds (ie, club kids, college kids, etc) seeking it for recreational use/misuse. This is why anyone who seeks it out should be fully aware of its side effect potential and profile, as there is no one universal panacea for anything.

    Sometimes just seeking help is enough to generate a placebo effect that is enough to promote a person through their obstacle without having to stay on any substance for very long at all. After all, we get what we expect to get out of things, and sometimes we get what we least expect.

    And yes, there are things that are quite scary from an outsider’s perspective, like the prospect of falling into a k-hole. But I do hope that esketamine is not so chemically different than ketamine itself (which is a Controlled Substance in the USA now) that it works along the same routes. Otherwise, comparing the two is really subjective.

  • Well, no kidding about serotonin. Serotonin isn’t our only happy neurotransmitter/hormone/etc either! All of our neurotransmitters and hormones tend to affect all the others in some way anyway, esp bc the brain is trying to overcompensate for the imbalance in its natural state by the drugs.

    From what I’ve read about the placebo effect, it can be mostly halted with naloxone, which leads researchers to believe that the placebo effect is associated with our endorphins, which is a powerful system that affects many other areas of the brain and body thru its action. Not only can it boost our moods and lower pain, but it can induce feelings of thinking things are just fine and peachy and going all right. Not only are endorphins affected, but our reward system including dopamine is activated, which can also reward the self for “believing that he/she is doing better” even if that is just from placebo.

    This of course is why all clinical studies test new medications or treatments test vs placebo. If anything can’t outperform our own body’s way of handling these things we are treating, why even release it? Some doctors actually prescribe placebo pills, too.

    Even the expectation of getting something that can fix the situation can bring about a placebo-type effect, like when drug addicts call their dealer while dopesick and suddenly they aren’t dopesick anymore as they expect their fix to arrive.

  • I think the idea of saying the formation of spirituality and faith is just mere delusion is pretty inaccurate and very prejudice. Many scientists have argued that spirituality and the formation of religion is based on a basic genetic need to socialize and share hope, love, and experience. Some brain chemicals like DMT have been linked to spiritual visions and are still in use by shamans and their “churches” today in Ayahuasca for visions, healing, and spiritual healing. There are so many things that some people truly do experience and call it a “spiritual awakening.” They are not delusional. Just because you as the author have not had one yet or even seem open to the idea that modern religion has become more of a social way of releasing things that people do not have control over in their lives, giving it up to “a higher power,” even if the higher power is the social concept of a church or religious experience.

    I think that to oversimplify every single religion or spiritual practice across time and the world by discounting it as just delusional psychosis even that is ingrained in everyone (why would evolution make people delusional for the sake of … what? Unity?), really means the author has not really studied the individual experience and group experience of non-commercialized religion across the world and throughout history. Surely, some people have been a little nuts and mad in their beliefs, but that cannot discount every single person and every single experience that has happened even if once in their lives.

    Not every spiritual practice is about healing the sick like you see on TV evangelical propaganda, nor about cursing others. Most people find themselves at least spiritual to some degree, even if there is no proof of a god or goddess or multiple deities. Not every spiritual practice lacks value or wants your money and gives false hopes and promises.

    I agree that some religions have waged war to spread their message to the unbelievers and even some of our holidays in the USA are based around pagan rituals that some major religion like Christianity has contorted by changing the details and making it their own (ie, Christmas, Easter, etc).

    Anyway, I just wanted to share that to call every spiritual experience as delusion and psychosis is to really undermine each person’s right to believe in the unknown as a possibility… I certainly wouldn’t discount some of the things I have seen and experienced myself as a situational one time delusion or psychotic moment, esp since I have had delusions and psychosis thanks to psychotomimetic psychotropic prescribed medications (not on purpose!) and know the difference.

    Some spiritual practices are designed to induce euphoria, ecstasy, and a feeling of being connected to life itself with compassion, not judgment. It’s true that you may have to really search these out nowadays, due to the way modern mainstream religions have become institutional and commercialized and about profit.

    Atheism is just another cult of structured beliefs in itself and not excluded by group membership and like-mindedness as a collective “belief system” that also isn’t proven either.