Thank you Philip Hickey for your elegant, readable deconstruction of the recent version of the dopamine hypothesis. Researchers with years of training and experience should know that even statistically different mean values do not establish that meaningful differences exist between two groups if the individual values in both groups largely overlap, and if the group sizes are small. Unfortunately, studies with small samples are common in neuroscience. They overestimate the strength of postulated relationships and yield findings that are very difficult to reproduce. The systematic construction of ignorance is an expensive, wasteful, and dangerous activity.