Martin Harrow and Thomas Jobe’s research is to be commended. It is a game changer. Harrow and Jobe have worked quietly in the trenches for over two decades, foregoing no doubt— lucrative careers in industry and/or medicine. Until recently Harrow and Jobe’s research and scholarship was utterly dismissed by pharmaceutical companies, and their formidable public relations personnel. David and Goliath 2013. Harrow and Jobe’s work is remarkable and inspiring.