Tuesday, February 18, 2020

Comments by Micki

Showing 3 of 3 comments.

  • I have not really followed this site, but I have the read the book Mad in America and I admire it so very much.

    I am sharing about vitamin K2 as it affects cognitive function and mood.

    I am unfamiliar with the supplemental programme mentioned here, but I have been actively reading about vitamin K2 for some time and it is a topic that is about to come into its own soon and you will be hearing about it.

    Vitamin K2 is a form of vitamin K that we have impaired in recent times. Vitamin K of all forms are among the fat soluble vitamins (A, D, E and K) and vitamin K2 is found in many forms. K2 has side chains of varying lengths and vitamin K2 is called menaquinone. So MK-4 is menaquinone with a 4 link side chain. MK-7 is menaquinone with a 7 link side chain. As the chains get longer, the vitamin K2 become more lipophilic.
    Menaquinones are created by bacteria, but MK-4 is the common form that is NOT created this way. We can consume MK-4 in food, but the interesting thing is that we also make it endogenously. We foul up this biosynthesis via some Rx drugs and also via trans fatty acids, which are created when high vitamin K1 oils are hydrogenated. Trans fatty acids are really biomarkers of an aberrant form of vitamin K called dihydrophylloquinone (dK). dK cannot activate vitamin K-dependent proteins and impairs biosynthesis of MK-4.
    The brain has the highest amount of MK-4 in the body, but the pancreas is also high, as are kidneys and other organs.

    There is some compelling evidence that we need much more vitamin K2 in diet and we need to stop blocking the biosynthesis of MK-4. It makes for brain/mood issues, it increases risk of diabetes, it leads to increased risk of CHD, it leads to increased risk of cancer, it impairs health in general.

    Guylainne Ferland is from Montreal. She is doing exciting things with vitamin k and brain.
    Look into her.

    Brains need MK-4 and I suspect that the drugs so often cited here also impair MK-4 biosynthesis (as do statins, bisphosphonates, NSAIDs). So this is an argument for supplementing if you do not get K2 in diet.

    Long chain K2 is high in some fermented foods (cheeses, natto, some in sauerkraut or yogurt, organ meats, mollusks or insects) and, while it is true that our gut bacteria make it, it is for them and for their energy and we absorb very little from out gut bacteria. MK-4 is high in animal fats (butter, lard, the fat itself, egg yolks). So we have lost the foods high in vitamin K2 due to bad dietary advice.

    The blocking of MK-4 biosynthesis via trans fatty acids and Rx and OTC drugs is another aspect of why brains need this so very much.

    Supplements are no substitute for real foods, but we have lost those. We forget about what real food was in just a few decades back. Now folks are malnourished and especially deficient in fats and fat solubles. Like in the brain.

    So do not ‘dis’ supplements, but do seek fats and fat soluble nutrients and do avoid drugs that impair them.

  • That is what so many doctors think and it is MUCH more nuanced; doctors and nutritionists have really misunderstood vitamin K, so even they make this mistake. IF someone is on warfarin (Coumadin), then they are admonished to watch intake of vitamin K. They spend a great deal of time and many doctor visits monitoring what is known as INR, which is the rate that their blood coagulates. It must be held within a very tight range and this is done by monitoring and adjusting warfarin dosage and trying to keep vitamin K intake at a steady rate.
    However, the reason for the new class of drugs that work with coagulation/clot prevention is that warfarin leads to inappropriate calcification – a pretty bad side effect. That is, those on warfarin tend to calcify and they are at higher risk of CVD (I know, ironic) because of this drug and this increases risk of dementia, etc. OR, if they are taking too much warfarin or alter their intake of vitamin K to be greater, then they tend to bleed too much or hemorrhage. See? This phenomenon is about the effects of K on those on this fairly common drug – and this is a valid danger.
    However, does too much vitamin K cause too much coagulation in those NOT on this class of drugs…a question some medical experts even ask (!)? No. Vitamin K cannot be overdosed because of how it works (with those on Coumadin et al being the exceptions, and even THEN, there is evidence for better ways to control coagulation). We activate certain proteins in a convoluted process with the usage of vitamin K as an activator of an enzyme/gene that activates these certain proteins. These are called vitamin K-dependent proteins. They are diverse, found throughout the body in specific types in specific tissues/organs and in specific amounts, and they are only recently being appreciated for the incredible power that they hold. So PubMed ‘vitamin K-dependent proteins.’ Learn about them.
    The first ones identified were all about the so-called coagulation cascade – the ones we ‘dink with’ when we use warfarin/Coumadin and they were the only ones known for about 4 decades after Henrik Dam actually identified vitamin K in the late 20/early 30s. We studied these 7 vitamin K-dependent proteins to death and there is an incredible amount of literature about the topic of anticoagulants and vitamin K. Only now it is becoming recognized that OTHER vitamin K-dependent proteins such as MGP, osteocalcin, periostin, Gla rich protein, Gas6, etc are everywhere and doing all kinds of things that we sort of missed! Some of the newest insights are only a couple/three years old! The coagulation cascade is so essential for life that it is tightly controlled via what is called the vitamin K cycle, ensuring coagulation is controlled even without enough dietary vitamin K or even enough MK-4 biosynthesis. Docs all over have been taught that if someone’s blood coagulation rate is okay, then they are K replete. However the vitamin K-dependent proteins beyond the coagulation cascade tend to have a pretty sizable percentage as inactivated (and this percentage of inactivated vitamin K-dependent proteins INCREASES with age!) and this leads to some bad things. See? Disease of aging could represent long-term effects of subclinical vitamin K deficiency; this is the Triage Theory about vitamin K (look it up!) posited by Bruce Ames.
    http://ajcn.nutrition.org/content/90/4/889.full.pdf
    If ostecalcin is inactivated, it means that the bones/teeth/cartilage/nerves/brain and other areas where this protein is found are making slightly defective proteins and this means that calcium is dysregulated, cholesterol is dysregulated, and the tissues are not optimally healthy. BTW, generally, menaquinones regulate inflammation, cholesterol, calcium, gene expression – all really important roles and ones which we have messed up and ones which we have poorly correlated with this nutrient/hormone status.
    Cancer is implicated in mucked up vitamin K. CVD and fracture risk are definitely implicated in the literature, too. So is brain health…and this is what I am pointing out! If we are to address the damage from psychotropics… If we are to prevent mental illness… If we are to actually understand the mechanisms of brains… Then we need to address menaquinones ASAP.
    http://www.ncbi.nlm.nih.gov/pubmed/22419547
    Vitamin K, an emerging nutrient in brain function.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891353/
    Age- and brain-region-specific effects of dietary vitamin K on myelin sulfatides
    Just two examples of what is out there. There is much more.
    So my claim is that Americans are totally insufficient in vitamin K. We lost long chain menaquinones in our diet entirely. We hinder the endogenous process of MK-4 biosynthesis via drugs and food and probably some endocrine disruptors. We actually eat more veggies these days (I know, this is not what we are told) but I think that our alteration of dietary fats has inhibited their bioavailability. We are, as a nation, insufficient in vitamin K, especially K2. And this affects brains.

  • I have been extensively looking at the nutrient/hormone/antioxidant/gene regulating substance vitamin K2, the menaquinones. It is extremely high in the brain, in the myelin sheath, but it is also very high in other tissues and other organs. It appears that the brain and the nervous system depend on optimal biosynthesis of MK-4 from dietary vitamin K and that long chain dietary menaquinones are possibly better absorbed than dietary phylloquinone.
    As I consider the scathing indictment of psychotropics, it seems that dietary menaquinones might very well be healing of their damage and therapeutic to those suffering from a variety of mental and neurological ills.
    G Ferland of Montreal has written on this (worth the read), but there are others, too.
    Are you at all interested in making some of this come to trials – to offer true hope that no one will fund as potential because there is no big money to be made?
    As it stands today, we consume less long chain menaquinones due to loss of fermented foods and organ meats and possibly such traditional foods as insects and mollusks.
    American cheeses lack the long chain menaquinones of those from countries that still follow traditional practices.
    You have helped so many just showing the corruption and effects. Please help more by going beyond just pointing out how very bad so many drugs are, and help to show that this vast family of nutrients/hormones offers real solutions! There is no one to make money on this, just a changed diet and improved health. It flies in the face of pharma AND the food industry, the two of which are the largest industries in the US.
    MK-4 biosynthesis is hindered by certain drugs: statins, bisphosphonates, warfarin (and I think SSRIs but I know of no one who has looked).
    Also, dihydrophylloquinone hinders MK-4 biosynthesis and this dominates American fast foods and processed foods.
    All these substances that interfere with MK-4 biosynthesis impair many aspects of health, including mental health.
    Only who can go here?? Please help. Please contact me and allow me to share the case for vitamin K2 in health of all kinds, including mental health.
    Thank you.