I have not really followed this site, but I have the read the book Mad in America and I admire it so very much. I am sharing about vitamin K2 as it affects cognitive function and mood. I am unfamiliar with the supplemental programme mentioned here, but I have been actively reading about vitamin K2 for some time and it is a topic that is about to come into its own soon and you will be hearing about it. Vitamin K2 is a form of vitamin K that we have impaired in recent times. Vitamin K of all forms are among the fat soluble vitamins (A, D, E and K) and vitamin K2 is found in many forms. K2 has side chains of varying lengths and vitamin K2 is called menaquinone. So MK-4 is menaquinone with a 4 link side chain. MK-7 is menaquinone with a 7 link side chain. As the chains get longer, the vitamin K2 become more lipophilic. Menaquinones are created by bacteria, but MK-4 is the common form that is NOT created this way. We can consume MK-4 in food, but the interesting thing is that we also make it endogenously. We foul up this biosynthesis via some Rx drugs and also via trans fatty acids, which are created when high vitamin K1 oils are hydrogenated. Trans fatty acids are really biomarkers of an aberrant form of vitamin K called dihydrophylloquinone (dK). dK cannot activate vitamin K-dependent proteins and impairs biosynthesis of MK-4. The brain has the highest amount of MK-4 in the body, but the pancreas is also high, as are kidneys and other organs. There is some compelling evidence that we need much more vitamin K2 in diet and we need to stop blocking the biosynthesis of MK-4. It makes for brain/mood issues, it increases risk of diabetes, it leads to increased risk of CHD, it leads to increased risk of cancer, it impairs health in general. Guylainne Ferland is from Montreal. She is doing exciting things with vitamin k and brain. Look into her. Brains need MK-4 and I suspect that the drugs so often cited here also impair MK-4 biosynthesis (as do statins, bisphosphonates, NSAIDs). So this is an argument for supplementing if you do not get K2 in diet. Long chain K2 is high in some fermented foods (cheeses, natto, some in sauerkraut or yogurt, organ meats, mollusks or insects) and, while it is true that our gut bacteria make it, it is for them and for their energy and we absorb very little from out gut bacteria. MK-4 is high in animal fats (butter, lard, the fat itself, egg yolks). So we have lost the foods high in vitamin K2 due to bad dietary advice. The blocking of MK-4 biosynthesis via trans fatty acids and Rx and OTC drugs is another aspect of why brains need this so very much. Supplements are no substitute for real foods, but we have lost those. We forget about what real food was in just a few decades back. Now folks are malnourished and especially deficient in fats and fat solubles. Like in the brain. So do not ‘dis’ supplements, but do seek fats and fat soluble nutrients and do avoid drugs that impair them.