Why are you connecting anticholinergic (aCH) drugs to antidepressants and antipsychotics? This is incorrect. Antidepressants and antipsychotics are not aCH based and don’t work on the same neurotransmitters. Anticholinergic (aCH) drugs are given with antipsychotics when the latter induce movement side effects (EPS) like parkinsonism and others. Anticholinergic (aCH) drugs are mostly given in the first years of diagnosis of Alzheimer’s Disease under the assumption that it might slow down the disease’s progression. This might be wrong and even lead to the contradictory results, as indicated by the paper you review. Again, this was shown to be the case for a genetic sub-type. So please, even if there is a lot of wrong doing in the pharma industry and the medical practice, it is important to not spread misinformation.