I recently finished reading Dr. Brogan’s book, which is impeccably written. I do have a question. Dr. Brogan writes, “These cases appear to occur predominantly in people who have genetic variants that reduces their liver’s ability to metabolize drugs, compounded by the use of multiple medications.” Could this suicidal-preoccupation and/or akasthesia be brought on from having been on numerous medications for many, many years? In my own case, I have now been on medications for 15 years total. Starting about five and a half years ago, I started experiencing a lot of problems with many medications. Some of them are physical problems that I now experience with anti-psychotics. But also, medications that used to help me will sometimes have new, bizarre effects. For example, if I take clonazepam too many days in a row, I become suicidal. This never used to happen. I wonder if this is what Dr. Brogan is speaking about? Regarding the physical symptoms, I’ve been to a couple neurologists, and they can find nothing wrong with me, including on the MRIs of my brain and spine. They then tell me the symptoms must be all psychosomatic, and I should consult a psychiatrist. Never mind that the pdoc was the one to tell me to see a neurologist!