Monday, September 21, 2020

Comments by Bill_in_Australia

Showing 3 of 3 comments.

  • An excellent link Barbara.

    For my thinking it is typical that the paper doesn’t go far enough. It assumes that antipsychotic drugs simply occupy the receptors and that is the end of the story. If that were the case there would not be a link to smoking. The reaction of the synapse to the blocking of receptors is probably twofold: more receptors and reduced re-uptake. The net result is an increased in sensitivity to increases of D2 above the normal levels. Thus the addition mechanism for nicotine is enhanced.
    An interesting follow up experiment would be to see if smokers given antipsychotics for the first time, lose to urge to smoke temporarily until they adapt to the receptor blockage (and then take it up with a dramatic severity). Smokers reporting of relative enjoyment of cigarettes at various stages of antipsychotic adaptation could also be an interesting measure. This could also give a way to measure the time taken to adapt (roughly).