I appreciate all that is written here. Instinctively, I have not liked anti-depressants and the few times in past I went on them for anxiety, they made me panic and I hated the experience. Despite what doctors dismissing my feelings on how they made me feel, my problems didn’t amount to enough to stay on them. I wish i could say that was the end of it but it was not. After a major life event (one that includes a life-ending disease), I had a major bout of depression. I tried to avoid anti-depressants and certainly cannot say I was “well” but I went to counselling and I went to a stop-smoking clinic and was trying to get well despite a pretty bad prognosis I would forever have to live with. I spoke with an NHS assessor and he suggested anti-depressants and as I wasn’t well, I thought I’d try them again. Big mistake – I think anyways. I panicked badly, was shaking and with a whole lot of real problems, it was pretty bad. I had to get off of that prescription and move to a lesser one. Which I did but the shock of that experience stayed with me and for an already depressed person, this was an event that put my vulnerable system through h*ll and, I feel, made my journey that much harder. During those first few stages of the 1st meds and getting onto the 2nd, all stop smoking well stopped, in point of fact I went from a 4 a day smoker, who was trying to quit…to someone who cleared about 400 cigarettes in about a month’s time…while I got on one, suffered on it, left it and then “acclimated” to another. They say anti-depressants make you worse before better and I certainly experienced that worse. I am not sure if that worse is good for everyone. Sometimes a person cannot take that last dose of really bad. Maybe that is indicative of something really wrong with me, but obviously, I read these articles and feel a kinship with those who have not found it good and who have not seen this as the path of all good things, because my experience was not good. However, in saying that what I feel most people, especially those who are depressed, would like to see is understanding of them and their feelings – not for doctors to see them as non compos mentis as depression makes you unable to assess anything and if you state the meds are making you feel this way, they see it as you probably are stressed and that is the reason, not the meds. This article is helpful in giving that understanding to those who don’t fit the medical box. The second is that they seek hope but that is a really difficult one to get. Most articles state how difficult it is once a major depression hits to not have a relapse. Articles about anti-depressants state going on meds is your best way to not have a relapse. Articles denying that state that anti-depressants will more than likely bring about a relapse. So for some meds are great but for those it isn’t so great for, what is the path? I am in agreement with the general sense of the article, I am just not sure for the depressed where it leaves them if they want hope for a future without depression. What alternatives are there? Of course counselling, exercise, nutrition but major depression is some pretty bad chemicals – so I guess I think that articles such as this should give some ideas of how to deal with something this terrible so that readers who feel an affinity with your message can also feel hope and not just a dark idea that because I’ve taken these drugs, I have committed my self to future of more problems than if I hadn’t. Also, I think that there should be guidance with counselors to not just promote anti-depressants. Maybe there should be some guides out there that help you through a depression through a series of different methods – like nutrition, like encouraging a little exercise, like vitamins or even herbal remedies before going to the strong stuff. All the first items are, are trials to see if there are good opportunities to get well without taking something that clearly states that it is common for those taking it to become more depressed in the beginning, can be prone to suicide…these are not good for someone who is anxious and depressed. So for those in the health field, please read about how a patient might want to be treated and take that into account. Secondly, for the author of this article…I agree with your sentiments that medicine (even ECT as I see in your comments) might not work but don’t give the message to depressed people that all venues and roads offered by doctors or ‘the professional medical members’ won’t work without proposing some hopeful and helpful alternatives. Spouting resonating feelings peppered with doom and gloom will not help depressed members reading this.