Monday, November 28, 2022

Comments by opusensemble

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  • Thank you Robert for your tremendously relevant work, definitely worthy of the Pulitzer Prize for Public Service.

    I stumbled upon Anatomy unfortunately only after getting profound iatrogenic damage and seeing my life shattered to pieces after 1 decade exposure to one SSRI.

    As unipolar depression & TRD (a good % of it arguably tardive dysphoria) classic treatment algorithm proposes augmentation with the family of atypical anti-psychotics, and although this recommendation seems to orbit around the studies by Lilly on fluoxetine+olanzapine combination (a marriage made in heaven), and Abilify+SSRIs, I wonder if the long term outcome in this clinical application would yield at least mixed results as well, specially considering the serious life threatening risks of this augmentation agents.

    Although TRD algorithm recommends non-systemic approaches when augmentation agents like atypical APs fail, only a very tiny fraction of the patient population will have access to them. Probably more than 99.9% of cases of TRD (at least in Europe) will get indefinite treatment with a revolving door of medication attempts, many of which use anti-psychotics. The vast majority of patients are stuck in this hamster’s wheel, and the low response rate in the clinical trial makes one expect that most of them are dealing with permanent treatment inefficacy and intolerance which doesn’t do much more than keeping them sedated, in the absence of a better treatment approach.

    I wonder if metadata could be derived from existing studies on the long term impact of depression treatment augmentation with atypical anti-psychotics as the patient population is dramatically higher than in schizophrenia.

    And if the oppositional tolerance hypothesis proves correct on this class of meds, maybe it’s legitimate to suspect on increased chances of having induced tardive-psychosis at comparable rates to tardive-dyskinesia.

    The widespread use of atypical-antipsychotics in hard-to-treat depression management could probably deserve some closer investigation, considering the big piece of the pie it gets from this increasing patient population.

    I hope you can come across metadata in this realm in the future although this article and study conclusions alone are good predictors of what the answer for that question might be.

    Never let your thirst for truth fade away. You are already a living legend.

    Heartful cumpliments from Portugal,
    Joao Gaspar

  • I can truly relate to this topic. My life was destroyed by Pfizer’s Zoloft.

    After taking Zoloft for 11 years prescribed for my first major depression episode, I suddenly experienced a worsening of all symptoms overnight, to the point I thought I had stroke. Went to the hospital, made CAT and MRI scans and it all came out normal.

    I always thought Pfizer and my doctor were my guardian angels, but now I know in hindsight that they were my undertakers in disguise. The truth about long-term anti-depressant has been swept under the rug all these years to the point that it is now becoming the pink elephant in the room. `

    I only wish I had a way to make Pfizer held accountable for the damage I know Zoloft has made me. I feel I have been silently lobotomized. It was the perfect crime, as days before that fateful day last year, I would have swear on the bible that Zoloft was my life-saver. I feel I simply have overclocked my brain over the years until one day, without any warning sign not only it stopped working, as became burning gasoline in my brain, and I wasn’t able to stop the fire ever since.

    When I told it to my doctor he just didn’t believed that Zoloft could have changed its effects so dramatically and ordered me to double or even triple the dosage until it worked again. That only added fuel to the fire. I made this diagram depicting my pharmacological path:

    Once I upped the Zoloft dosage I got into a permanent anxiety and agitated state of despair, near to psychosis but without hallucinations.

    Since the day that Zoloft has failed on me I have been experiencing a permanent burning sensation in the left frontal side of my brain, accompanied with constant painful and despairing sensations of “pins and needles” in that part of the brain.

    I feel hopeless that no doctor could take these symptoms seriously, quickly labeling them as anxiety effects or “sensory hallucinations”. I’m aware that the brain doesn’t have sensory abilities but I also know my body and this is just not normal and it’s simply impossible for me to believe that it is of psychosomatic or somatic origins. It feels too painful and constant and there’s nothing I’ve found that is able to sooth it.

    I know that I was taking Zoloft for 11 years when this first appeared rendering useless all further medications, so there’s absolutely no doubt for me that Zoloft was the single responsible. Even if I try a single pill of Zoloft today I get a psychotic attack in a matter of hours, completely loosing my mind and ability to control myself, as if my skull contents were replaced by a gallon of burning acid, rendering impossible any controlling thought attempts.

    I’m just so sorry and feel so frustrated and helpless that I haven’t found Robert Whitaker’s books years ago, as it would probably had saved me my life. Now I feel it is too late. Pfizer has lobotomized me. And I feel ridiculous for being Portuguese, thinking that our Egas Moniz was a shameful example of medicine practice, only to find out that 65 years after his ridiculous Nobel prize, untrue science and dishonest clinical practice would still have a way of performing the same brutal surgery, now chemically through a psychiatrist with warm and harmless manners, silently through the years, one pill at a time.

    I always thought we lived in an age of science. When I attended university and back when I had an engineering job, I knew that the wrong bytecode in a critical piece of software could make airplanes crash, and make vital signs machines fail in hospitals, leading to the loss of innocent lives.

    Never did I suspected that there could be any science where the principles of forward validation where not met. How is it possible that drugs tested only for 6 weeks, become the long term treatment of patients over decades? How is it conceivable and acceptable in our age that such a science crude and primitive easiness is allowed? How can it be possible that these principles of the scientific method are not the de-facto measure used for new therapies’ approval? This is shameful, uneatable, unpalatable, unqualifiable.

    How can man conduct such a global scale experiment with genocidal contours, replacing the required medical engineering-validation by the nature validation using human guinea-pigs?

    Psychiatry should be in deep mourning mandated by regulators to re-invent itself. Regulators should be held criminally liable for the consequences of these drugs being spread and approved across all continents without consumers being warned of the TRUE potential risks of being chemically lobotomized.

    I was certainly unaware of the long-term risks of taking Zoloft. I was told by my doctor to think of it as insulin for diabetes. And now that I look in hindsight to what has happened and see it validated in Whitaker’s revelations, I am simply ashamed of living in this “modern age”. What psychiatry is making is not honorable and does not reflect the high standards of scientific validation in our times. What psychiatry profession is making is a medieval experiment fueled by Big-Pharma stockholders interests, banking at the cost of an ongoing genocide machine.

    I never believed in conspiracy theories but this is certainly one.

    My life is divided between my unrelenting agony and the admiration of Whitaker’s astonishing work. I couldn’t admire anyone more than I admire him. If I still have any willingness to live left, that is solely to honor his contribute to our age. He should have won the pulitzer prize. At least the CCHR award.

    Part 1: The Roots – Robert Whitaker – Psychiatric Epidemic – PsykoVision CPH – May 14, 2014

    Part 2: The Scope of the Epidemic – Whitaker – Psychiatric Epidemic – May 14, 2014

    I took his books to my shrinks’ offices in Portugal and urged them to buy them and start refraining from ruining lives. They are unconsciously being undertakers, not the guardian angels patients expect them to be.

    Long term Zoloft use rendered my MDD untreatable and left me with persistent agony of suffering a medieval torture of acid being poured over my Left-Dorso-Lateral-Pre-Frontal Cortex (Left-DLPFC)and sensations of pins and needles on my corpus calossum, together with sensations of mild cognitive impairment and fears of probably early onset dementia. I feel hopeless for having been chosen by fate for such a unusually reported adverse effect, but meanwhile any 5HT related drug that I take seems to deepen this suffering.

    I’m truly afraid of my doctors’ prescriptions and can’t seem to trust them anymore. After having found that SSRIs and APs and others are actually being validated by nature in real-time, and haven’t been validated previously long-term either by medical-sciences, either by nature, makes me completely loose trust in the whole medical system.

    I was even taking Agomelatine (Valdoxan) as the most tolerable drug I have found after Zoloft’s lobotomy, but knowing that Agomelatine is in the European market only since 2009, gives me the “dejá vu” feeling that it’s just the same trap. History repeating itself, and the same gross failures perpetuated yet over and over again. And God people, how history is important!

    Whitaker contributed a lot to the rise of the collective consciousness of realities hidden from mainstream media.

    The discussion brought up by Dr. Shipko is important but informed consent will most likely take decades to become a common practice.

    For the millions of wounded sufferers like me, forsaken by psychiatry in the battlefield once their depressions turn treatment resistant, (and regardless of their recovery odds), the question I would ask is the following:

    If you had one last decision to make in life, and that would be choosing between embarking in a journey of popping every new-long-term-unproven-by-science-and-nature fishing-bait-AD in the market OR refraining to take these drugs no matter what the brutal personal and social consequences to your life may be, what would your choice be?

    One can certainly take the drugs and bear the side effects for a while even if they’re not being effective to lift the underlying depression, but with which consciousness can we take them, knowing that a multi-generational, market fueled and science unintentional arcane experiment is being done at a global scale?

    It appears to me that regardless if one chooses to stay on meds that hardly yield benefits; withdraw painfully from these meds no matter if they were working or not; or embark on a journey of anti-meds fundamentalism, it looks quite self-evident that independently of the chosen approach, sooner or later we’re perpetuating ourselves as martyrs.

    If in the disproportionate fight of depression it seems there’s no such thing as a free lunch, what type of martyrs do we want to be or will we able to be? With which help? And at which cost?