Actually there is not much truth to what you write. Learned helplessness is a concept arising from animal studies conducted by psychologist Martin Seligman. It refers to a situation where one cannot escape from a frustrating situation, like caught between a rock and a hard place. Learned helplessness signifies the relationship between an organisms and its environment. Inflammation and increased stress hormone release are a result of acute or chronic stress, distressing life events, childhood traumas, low socio-economic status, overweight, insomnia among others. These are factors that precede any form of depression or its medication. Inflammation and stress hormone release are involved in many illnesses that have nothing to do with depression or its medication.