I think one of the things that is missing on this thread is that antidepressants do not resolve the root causes of depression, which means that – when medications are tapered – the underlying issues remain and depression can occur again. Inflammation, thyroid problems, vitamin deficiencies, allergic reactions to food, poor diet, poor gut function, can all play a role.. When people taper, it is a good idea to investigate these issues to try and determine what the reason for becoming depressed was in the first place. There is a growing body of evidence that depression is not a serotonin deficiency. The drugs are nasty, and withdrawal can be hell. But perhaps the reason so many people relapse years after quitting them, is because the underlying issues have not been addressed.