1. It is unnerving that the study 329 remain unregistered.
2. 97 out of 136 (71%) of the paroxetine studies registered at ClinicalTrials.gov remain unpublished over five years after their completion date.
3. ClinicalTrials.gov: paroxetine studies on childrens completed before Oct 2010: 14 studies:
– Two (n=2) of these studies recruited exclusively children patients (NCT01376128 and NCT00074815)
– One (n=1) study recruited children and adult patients.
– The remaining eleven (n=11) studies recruited patients of all ages (childrens, adult, and seniors).
– PubMed search: “The following terms were not found in PubMed: NCT00031317, NCT00025740, NCT01371435, NCT01371448, NCT01376128, NCT01371474, NCT00519012, NCT00100464, NCT00069225, NCT00009568, NCT00046553.”
– Only three records (out of fourteen) were found on PubMed: 15 publications (NCT00074815, NCT00594269, NCT00012558)
This study is also very interesting (no results & unpublished)
Ramirez, Jorge H; Casañas, Marc (2014): Paroxetine: analysis of unpublished human studies (observationals and clinical trials). figshare. http://dx.doi.org/10.6084/m9.figshare.1103284
James C. Coyne wrote: “Readers are encouraged to retrieve Kinderman’s blog post and see for themselves. It is posted at the anti-psychiatry blog, Mad in America.”
Re: I understand “anti/pro+X/Y/Z” labels (e.g., “anti-psychiatry”, “anti-industry”, “pro-academy”, “anti-depressants”, etc) as bad arguments.
Some articles which were originally written in your native tongue (my case is Spanish) could be a challenge for anyone willing to translate with accuracy their contents (e.g., Spanish to English). The article entitled “Loca de Rebeldia“ (NoGracias) is certainly one example of this situation. I started the translation of this article a few weeks ago with Marc Casañas (his native tongue is also Spanish). Below you can read the translation of the full text.
We believe this article is very important to understand a reality that very few are willing to openly discuss: political abuse of psychiatry. Please feel welcome to suggest any improvement to this translation, we will appreciate your feedback a lot.
—
There is a theory of the origin of schizophrenia in which a person could lose their head due to the exposure during their childhood of conflicting messages transmitted by – often their mothers – or anyone who is in charge of their upbringing. An extremely protective and controlling mother continuously depriving the autonomy of their child, but at the same time she acts emotionally distant, hostile, even threatening, without offering a minimum of affection to protect the mental stability of their child. These contradicting messages – according to this theory – could provoke the loss of the child’s models of reference, confusion arises without any possible way out, an irrational mind in the adulthood is the only possible certain outcome for this individual.”
– I read and understood the posting policy of Mad in America.
– This article was recently cited (a few minutes ago) in a response to an Medscape article by Dr. Lieberman: What does the New York Times have against psychiatry? http://www.medscape.com/viewarticle/838764 (February 18, 2015).
Re: A challenge for Dr. Lieberman
…”So here is our challenge to Dr. Lieberman. Please provide a list of randomized studies that show that medicated patients have a much better long-term outcome than the unmedicated patients. Please note that we are asking for studies that measure outcomes over the long-term, say for at least two years or longer, and are randomized, since you indicate there are many such studies. Please point out the “extraordinarily superior” outcomes for the medicated group. We presume the studies will focus not just on symptom control, but also functional outcomes.”… http://www.madinamerica.com/2015/04/challenge-dr-lieberman/
2. Please let me add the following to this challenge:
Dr. Lieberman: please provide a list of payments received by pharmaceutical companies not disclosing their data to Propublica – Dollars for Docs. https://projects.propublica.org/docdollars/
Payments received from Pfizer, Cephalon, Eli Lilly, AbbVie, UCB, and Johnson & Johnson (2009 – 2013):
Research = $381554 USD
Meals, travel, speaking, consulting, and combination = $114.993 USD
Total = $496.487 USD
Very interesting information indeed, thanks!
A few thoughts:
1. It is unnerving that the study 329 remain unregistered.
2. 97 out of 136 (71%) of the paroxetine studies registered at ClinicalTrials.gov remain unpublished over five years after their completion date.
3. ClinicalTrials.gov: paroxetine studies on childrens completed before Oct 2010: 14 studies:
– Two (n=2) of these studies recruited exclusively children patients (NCT01376128 and NCT00074815)
– One (n=1) study recruited children and adult patients.
– The remaining eleven (n=11) studies recruited patients of all ages (childrens, adult, and seniors).
– PubMed search: “The following terms were not found in PubMed: NCT00031317, NCT00025740, NCT01371435, NCT01371448, NCT01376128, NCT01371474, NCT00519012, NCT00100464, NCT00069225, NCT00009568, NCT00046553.”
– Only three records (out of fourteen) were found on PubMed: 15 publications (NCT00074815, NCT00594269, NCT00012558)
This study is also very interesting (no results & unpublished)
Special Drug Use Investigation for PAXIL Tablet (Pediatric Panic Disorder)
https://ClinicalTrials.gov/show/NCT01376128
—
Reference
Ramirez, Jorge H; Casañas, Marc (2014): Paroxetine: analysis of unpublished human studies (observationals and clinical trials). figshare. http://dx.doi.org/10.6084/m9.figshare.1103284
James C. Coyne wrote: “Readers are encouraged to retrieve Kinderman’s blog post and see for themselves. It is posted at the anti-psychiatry blog, Mad in America.”
Re: I understand “anti/pro+X/Y/Z” labels (e.g., “anti-psychiatry”, “anti-industry”, “pro-academy”, “anti-depressants”, etc) as bad arguments.
“Pro/anti-psychiatry” – The Oxford Handbook of Philosophy and Psychiatry
https://books.google.com.co/books?id=XzlpAgAAQBAJ&dq=%22pro-psychiatry%22&source=gbs_navlinks_s
http://plato.stanford.edu/entries/psychiatry/
When a fan of Peter Gøtzsche criticises​ Peter Gøtzsche http://chaoticpharmacology.com/2015/10/01/cuando-un-fan-de-peter-gotzsche-critica-a-peter-gotzsche/ (by Marc Casañas, article in Spanish, translation in progress).
http://www.madinamerica.com/2015/09/10-of-the-worst-political-abuses-of-the-psychiatric-and-psychological-professions-in-american-history/
(translation English to Spanish in progress)
http://www.breggin.com/psychiatrysrole.pbreggin.1993.pdf
“Loca de rebeldĂa (crazy of rebellion)
Some articles which were originally written in your native tongue (my case is Spanish) could be a challenge for anyone willing to translate with accuracy their contents (e.g., Spanish to English). The article entitled “Loca de Rebeldia“ (NoGracias) is certainly one example of this situation. I started the translation of this article a few weeks ago with Marc Casañas (his native tongue is also Spanish). Below you can read the translation of the full text.
We believe this article is very important to understand a reality that very few are willing to openly discuss: political abuse of psychiatry. Please feel welcome to suggest any improvement to this translation, we will appreciate your feedback a lot.
—
There is a theory of the origin of schizophrenia in which a person could lose their head due to the exposure during their childhood of conflicting messages transmitted by – often their mothers – or anyone who is in charge of their upbringing. An extremely protective and controlling mother continuously depriving the autonomy of their child, but at the same time she acts emotionally distant, hostile, even threatening, without offering a minimum of affection to protect the mental stability of their child. These contradicting messages – according to this theory – could provoke the loss of the child’s models of reference, confusion arises without any possible way out, an irrational mind in the adulthood is the only possible certain outcome for this individual.”
– Read more: http://chaoticpharmacology.com/2015/10/04/6581/
—
Loca de rebeldĂa
17 febrero 2015 by Enrique Gavilán in Demedicalize-it – 8 Comments
“Hay una teorĂa del origen de la esquizofrenia que dice que si una persona recibe mensajes contradictorios por parte de la persona encargada de su crianza, generalmente de la madre, corre el peligro de perder la cabeza. Una madre demasiado protectora, que priva de su autonomĂa al hijo, controlando todos sus movimientos, pero que al mismo tiempo se comporta de una manera emocionalmente distante, hostil, incluso amenazante, y que no ofrece el cariño necesario para el equilibrio mental del niño, puede contribuir a que Ă©ste pierda todos sus marcos de referencia y termine, confundido y sin salida, abandonando el juicio.”
– Leer más: http://www.nogracias.eu/2015/02/17/loca-de-rebeldia/#sthash.NNgBKq2X.dpuf
Dear Katie,
Very interesting story.
Could you tell me more about how you got banned from Dr. Hassman site?
Kind regards,
Jorge
P.S. Welcome to chaos xD. http://chaoticpharmacology.com/2015/10/06/mad-in-america-10-of-the-worst-political-abuses-of-the-psychiatric-and-psychological-professions-in-american-history/
Dear Bruce,
Please take a look to my story: http://doc2doc.bmj.com/forums/open-clinical_medicolegal_requesting-legal-advice-whistleblowing-political-abuse-of-psychiatry=
Sincerely,
Jorge
Please take a look: http://bit.ly/1VUgJ4K
Dear Sirs, Mad in America,
– This is my first comment on this website.
– I read and understood the posting policy of Mad in America.
– This article was recently cited (a few minutes ago) in a response to an Medscape article by Dr. Lieberman: What does the New York Times have against psychiatry? http://www.medscape.com/viewarticle/838764 (February 18, 2015).
Re: A challenge for Dr. Lieberman
…”So here is our challenge to Dr. Lieberman. Please provide a list of randomized studies that show that medicated patients have a much better long-term outcome than the unmedicated patients. Please note that we are asking for studies that measure outcomes over the long-term, say for at least two years or longer, and are randomized, since you indicate there are many such studies. Please point out the “extraordinarily superior” outcomes for the medicated group. We presume the studies will focus not just on symptom control, but also functional outcomes.”…
http://www.madinamerica.com/2015/04/challenge-dr-lieberman/
–
Response:
1. Please let me help Dr. Lieberman to start disclosing the requested list of randomized studies:
http://chaoticpharmacology.com/2015/01/14/psychiatric-research-misconduct-at-the-university-of-minnesota-cafe-study-nct00034892-cc-fearloathingbtx/
2. Please let me add the following to this challenge:
Dr. Lieberman: please provide a list of payments received by pharmaceutical companies not disclosing their data to Propublica – Dollars for Docs.
https://projects.propublica.org/docdollars/
Payments received from Pfizer, Cephalon, Eli Lilly, AbbVie, UCB, and Johnson & Johnson (2009 – 2013):
Research = $381554 USD
Meals, travel, speaking, consulting, and combination = $114.993 USD
Total = $496.487 USD
Source: Dollars for Docs – Propublica
https://docs.google.com/spreadsheets/d/1jQ9n0yG0tu-G64c6EjjGAA3WHYgzTzHqUSKzegaXCqA/edit#gid=0