Good article Dr Fava. As someone who has lived with a “persistent post withdrawal disorder” for over 10 years now I hope there is a lot more research into it. I think it’s too late for me but I believe SSRIs would be used much less if patients (and doctors) really knew all of the potential harms. Once we have good research into the lasting harmful effects it will become very difficult to deny it. Then hopefully in the future people like me won’t be given an SSRI after a 5 minute conversation with a doctor. You wrote “antidepressants are life-saving medications”, what is this belief based on? Obviously as someone who has been permanently harmed by these drugs I’m very sympathetic towards the criticisms of them (as I’m sure many members of this site are). As far as I know these drugs only show a very small average difference from placebo and no difference in mortality. Is there any good evidence that they are life-saving even for a small number of people?