Hi James, I appreciate the fact for someone who has TRD, there is no light at the end of the tunnel and DBS would be seen as appealing. Problem is that the device manufacturers are attempting to go to market far too soon and at the cost of hundreds of sufferers who become their guinea pigs and with limited rights. Additionally, the lack of support when something does go wrong is what differs that from the proceedures you mentioned in your post. The fact is that DBS for TRD is plagued with problems and has been for many years. SJM continue to “hide” around the facts of their clinical trials which they have been supporting. Why not share the results openly…and now…..rather then simply saying that they are coming. Informed consent is a wonderful thing; when you are fully informed. Unfortunately medical companies fail to fully inform potential patients about what can go wrong. Medical ethics would dictate that a patient has all the facts prior to agreeing to a proceedure which is not proven and is still very much in the experimental phase. I agree it is down to individual choice, and appreciate the aspect of there being the element of desperation. Full disclosure however and honesty is required from the manufacturers and medical professionals who continue to “push” certain options.