AA I guess I’m meaning that the evidence that ketamine is helpful is available and it is not perfect for some very practical reasons. However what is known is sufficient for doctors and their patients to have a discussion of the risks versus the benefits of trying it for treatment resistant conditions. Professor Collen Loo in Australia has just today received a 2 million dollar grant to conduct a multi-center trial on 200 patients using ketamine versus an active placebo which will give us more information to work with. In any field new treatments invariably go through phases of excitement then despondency before eventually settling into “this is useful for some but not all.” Ketamine is the most widely used anaesthetic in the world and is on the WHO list of “Essential Medicines” to be stocked at all hospitals. This is because of it’s safety profile due to mimimal effects on respiration and the cardiovascular system. It continues to be used to manage severe pain conditions as well as being widely used in veterinary medicine.