In a study of 69,448 pregnant women with depression, researchers from the Harvard school of public health found that use of SSRI (selective serotonin reuptake inhibitors) during pregnancy were associated with a 1.22% greater chance of preeclampsia, SNRI (selective norepinephrine reuptake inhibitors) with a 1.95% greater chance, and TCA (tricyclic antidepressants) with a 3.23% greater chance. If the women had used these drugs prior to pregnancy, the chances of preeclampsia rose to 1.32%, 3.43%, and 3.26% respectively. Results will appear in the American Journal of Epidemiology.
Palmsten, K. Setoguchi, S. et al; “Elevated Risk of Preeclampsia in Pregnant Women With Depression: Depression or Antidepressants?” American Journal of Epidemiology, 175(10) 988-997
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