During the 1990s, researchers using MRI technology discovered that antipsychotics shrink the frontal lobes and cause an enlargement of the basal ganglia. In the “Follow-up Magnetic Resonance Imaging” study, researchers reported that the enlargement of the basal ganglia was associated with a worsening of both the positive and negative symptoms of schizophrenia. This was powerful evidence of how the drugs cause chronic illness over time.
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b) Neuroleptics in Progressive Structural Brain Abnormalities in Psychiatric Illness. Madsen, A. The Lancet 32 (1998):784-785.
c) Subcortical Volumes in Neuroleptic Naive and Treated Patients With Schizophrenia.Gur, R. American Journal of Psychiatry 155 (1998):1711-1717.
d) A Followup Magnetic Resonance Imaging Study of Schizophrenia.Gur, R. Archives of General Psychiatry 55 (1998):145-152.
Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.