NIMH’s First Follow-Up Study

a)  One Year After Discharge. Schooler, N. American Journal of Psychiatry, 123 (1967):986-995.

This NIMH study looked at one-year outcomes for 299 patients who had been treated either with neuroleptics or placebo upon their admission to a hospital. This was the first long-term study conducted by the NIMH, and the researchers found that patients who received placebo “were less likely to be rehospitalized than those who received any of the three active phenothiazines.” However, in spite of this finding, which the researchers wrote “was so unexpected,” the NIMH investigators stated that they “were unprepared to recommend placebo as treatment of choice.” (See page 991).

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