Second-Generation Antipsychotics Just as Likely as Older Drugs to Cause EPS

Kermit Cole

In a study of an earlier randomized controlled trial of antipsychotics, researchers from Yale and the U.K found that second-generation antipsychotics were as likely as the first-generation antipsychotics to cause extrapyramidal symptoms. However, patients in the second-generation group were "dramatically" (30-fold) less likely to be prescribed medication for the management of these side effects. First-generation antipsychotics have the potential to "avoid life-shortening metabolic disturbances" caused by second-generation antipsychotics, but current psychiatrists have little or no experience with the prior generation of antipsychotics, the researchers said. Results will appear in the British Journal of Psychiatry.

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Kermit Cole
Kermit Cole, MFT, is foundling editor of Mad in America. He worked in residential treatment with a focus on trauma & psychosis for many years before attending the first Open Dialogue trainings offered in the US. There he experienced the beauty and power of a network rather than an individual focus, and as a result came to love working with couples. He works at the Council for Relationships in Philadelphia, with an interest in couples and families that have "identified patients," but doesn't discriminate against people who are thought of as "normal."

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