Second-Generation Antipsychotics Just as Likely as Older Drugs to Cause EPS

Kermit Cole

In a study of an earlier randomized controlled trial of antipsychotics, researchers from Yale and the U.K found that second-generation antipsychotics were as likely as the first-generation antipsychotics to cause extrapyramidal symptoms. However, patients in the second-generation group were “dramatically” (30-fold) less likely to be prescribed medication for the management of these side effects. First-generation antipsychotics have the potential to “avoid life-shortening metabolic disturbances” caused by second-generation antipsychotics, but current psychiatrists have little or no experience with the prior generation of antipsychotics, the researchers said. Results will appear in the British Journal of Psychiatry.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]