Spontaneous Improvement in Depression, With and Without Placebo

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Researchers at Columbia University and Queens College reviewed 10 trials of antidepressants that used wait-listed controls in order to determine the contribution of spontaneous improvement to a positive placebo response. They determined that of a significant number of the 340 subjects improved “acutely” without treatment, but that the improvements did not in themselves account for the magnitude of the placebo response. Results will appear in an upcoming Journal of Psychiatric Research.

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Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.

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Kermit Cole
Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].

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