Blood Test for Depression Announced


Researchers testing the blood of 14 teenage subjects with major depressive disorder and 14 with no disorder for a set of candidate biomarkers from animal models of depression found that 11 of the 26 candidate markers differentiated depressed participants from controls. Results will appear in Translational Psychiatry.

Article → 

Note from Kermit Cole, “In the News” editor:
I have wrestled with including this item since it appeared a few days ago. The large flurry of news coverage, based on a small sample testing a rather broad assay of candidate markers, left me reluctant to present it as “news.” Such announcements are often trumpeted as the next big thing, with little notice that the results don’t pan out, while significant studies that question the basis for the standard of care garner little effective attention.

But the fact that a small, imprecise study can generate such a flurry of news could, as the “Daily Beast” points out, lead to large consequences, makes it important to include here.

“When something like this comes out and gets a lot of attention, it’s a false promise to parents, because it’s nowhere ready for prime time,” said Dr. Lloyd Sederer, medical director of the NY State Office of Mental Health in the Huffington Post. “Some of the risks have not been considered yet. And does it really shape, in any way, how effective your treatment is going to be now?”

I look forward to the responses of others in comments and blogs that I hope will come.

Related Items:
Los Angeles Times 
Scientific American
Daily Beast
CBS News 
ABC News
US News
Huffington Post


Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]


  1. I don’t think most people need a blood test for depression. If they don’t feel depressed, then why treat them? And if they do feel depressed, then we still don’t know the best thing to do. I suppose it might be useful in differential diagnosis, if it could differentiate between clinical depression and physical conditions such as metabolic problems, vitamin deficiencies or the onset of dementia. But this study was with teenagers, probably healthy, too.

  2. My take on fundamental flaws:

    – Extrapolating an analog of human depression from rat behavior. Unknown what cognitive deficiencies or unpleasant physical sensations have been induced in rat.

    – Given this, what the study has found is “marker” similarities between a (very small) human sample and unknown characteristics of specially bred rats.

    – Very tiny study samples, easily influenced by researcher bias.

    – Excessively optimistic projections of value of findings. False positive rates unknown.

    If this were taken seriously by psychiatry, which it will be because psychiatry is an unusually gullible profession given to fads, it will be used as an argument to medicate children even if the blood test is not actually available.

    Why? Because, simplistically, doctors (who should know better) will take this as evidence “depression” (however they define it) is biological and needs biological intervention, i.e. medication.

  3. A small sample size can actually mean a dramatic impact. It is actually very hard to find statistically significant values if the sample size is low, even if there is actually a difference between control and experimental group. For example, genetic variants that lead to subtle changes in metabolism that lead to human disease often need very large sample pools to find statistical differences(by creating a tighter standard error of the mean).
    Only very large differences can actually be suggested to be statistically distinct with a small sample size.

  4. The fact that this tiny “study,” having no scientific significance for several reasons cited in earlier responses, received massive media coverage does not suprise me at all. Media coverage is the result of public relations campaigns, marketing campaigns, and pressure from powerful interests. Dr. Peter Breggin and I have observed and analyzed that potent mix for decades. The acceptance, ascendance and complete authority of biological psychiatric theory is the best PR and marketing campaign ever executed. After the incredible marketing coup of Prozac, followed by the ‘Decade of the Brain’ it is inevitable that other companies will attempt similar campaigns to move their product.

    Finally, “biomarkers for depression” fits within the now culturally accepted paradigm that humans are their biology, and their feelings are biology, too. For discussion and details see psychiatrist Peter Breggin’s books Brain Disabling Treatments in Psychiatry, Talking Back to Prozac (2008), and Toxic Psychiatry among others.