High Attrition Leads to Misrepresentation of Antipsychotic Efficacy

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Researchers from Manchester and Melbourne assess the impact of high drop-out rates on  Cochrane reviews of five frequently prescribed second-generation antipsychotics. They found that all five reviews misrepresented the available evidence by including data from studies with unacceptable levels of attrition, often without any acknowledgment or justification. Results will appear in Acta Psychiatrica Scandinavica.

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Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.

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Kermit Cole
Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].

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