SSRIs: More Harm Than Good


Beginning with an “evolutionary analysis” and a review of serotonin’s role in the body, researchers from Canada and the U.S. conduct a thorough review of the evidence of antidepressants’ effect on the body and the outcomes for antidepressant treatment of depression. They find that antidepressants cause neuronal cell damage, as well as significant adverse health effects. The authors conclude that antidepressants “generally do more harm than good by disrupting a number of adaptive processes regulated by serotonin.” The study appears in Frontiers of Psychology.

Article → 

Related Items:
Press Release
Full Article
Antidepressants Do More Harm Than Good, Study Says
Report: Antidepressant medication may do ‘more harm than good’
“Happy Pills” Not So Happy: CBC Radio Interview with Author Paul Andrews
Antidepressants Do More Harm Than Good 
Happy pills can give you digestive problems and make you MORE depressed


Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.


Mad in America has made some changes to the commenting process. You no longer need to login or create an account on our site to comment. The only information needed is your name, email and comment text. Comments made with an account prior to this change will remain visible on the site.

Previous articleFormer Chair of DSM-IV Writes of “America’s False Autism Epidemic”
Next articleThe New York Times Magazine Article on Antidepressants
Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. I’m glad this article was posted at this time given the many articles like the one in the NEW YORK TIMES debunked on another blog here that keep attempting to deceive the public that SSRI’s are effective or safe when the opposite is true. Any honest, factual articles about the dangers and lack of efficacy of psychiatric drugs and ECT are critical since those with financial interests keep promoting these toxic treatments with support from industry and main stream media.

    Report comment

  2. Antidepressants cause more harm than good.

    This will not be taken as “news” for those who are involved in real reform in the field of psychiatry… The are (and many have been for quite some time) fully aware of this fact, and have attempted to spread the news, for quite some time.

    The only question is what will the 50,000 practicing psychiatrists do with this information?

    Practice as usual?
    Or reform?

    Many of us are watching to SEE what happens next.
    Not the talk.
    The walk.


    Report comment