Efficacy & Effectiveness of Treatment for Depression in RCTs & Daily Practice


A study from the Netherlands found that outcomes for 598 patients in treatment for mild to moderate depression were significantly less in practice than in meta-analyses for antidepressants, psychotherapy, or a combination of the two. Outcomes from the STAR*D trial were as poor as in routine practice. Results appeared online in Psychotherapy and Psychomatics May 11, 2012.

Abstract → 

van der Lem, R. van der Wee, N. van Veen, T. Zitman, F. Efficacy versus Effectiveness: A Direct Comparison of the Outcome of Treatment for Mild to Moderate Depression in Randomized Controlled Trials and Daily Practice, Psychotherapy and Psychosomatics, online May 11, 2012


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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].