A study from the Netherlands found that outcomes for 598 patients in treatment for mild to moderate depression were significantly less in practice than in meta-analyses for antidepressants, psychotherapy, or a combination of the two. Outcomes from the STAR*D trial were as poor as in routine practice. Results appeared online in Psychotherapy and Psychomatics May 11, 2012.
van der Lem, R. van der Wee, N. van Veen, T. Zitman, F. Efficacy versus Effectiveness: A Direct Comparison of the Outcome of Treatment for Mild to Moderate Depression in Randomized Controlled Trials and Daily Practice, Psychotherapy and Psychosomatics, online May 11, 2012
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