Review of Dietary Supplements for Depression


A review of dietary drug supplements for depression in the May issue of the Journal of Psychosocial Nursing and Mental Health Services finds that of the supplements reviewed (L-methylfolate, S-adenosyl-L-methionine [SAM-e], omega-3 fatty acids, L-tryptophan. and inositol], “only omega-3 fatty acids and SAM-e have sufficient supporting evidence for their efficacy to warrant safe use.”

Abstract → 


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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. From anecdotal reports and personal experience, omega-3 fatty acids (fish oil) seem to help many people.

    People tapering off antidepressants are reporting problems with SAM-e: It can be too stimulating, take care if your nervous system is sensitive.

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