A review of dietary drug supplements for depression in the May issue of the Journal of Psychosocial Nursing and Mental Health Services finds that of the supplements reviewed (L-methylfolate, S-adenosyl-L-methionine [SAM-e], omega-3 fatty acids, L-tryptophan. and inositol], “only omega-3 fatty acids and SAM-e have sufficient supporting evidence for their efficacy to warrant safe use.”
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These studies are quite frequently rigged.
For any reader who wants to know the facts about these type clinical studies, and how safe and effective vitamins really are in treating conditions like depression –
From anecdotal reports and personal experience, omega-3 fatty acids (fish oil) seem to help many people.
People tapering off antidepressants are reporting problems with SAM-e: It can be too stimulating, take care if your nervous system is sensitive.
I remember when St. John’s Wort was sold out (at more than one store) less than 10 years ago. I wonder if long-time, regular users would have anything to say these days.
I used SAM-e for a while and was very impressed. However I felt a little overstimulated and switched to a different supplement. It does work very quickly so users will notice effects within a day or two.