Ritalin Causes Long-Lasting Change in Prefrontal Neurons


Drexel University researchers found that methylphenidate (Ritalin) administered to juvenile rats produced significant depressive effects on pyramidal neurons. The authors conclude that “the juvenile prefrontal cortex is supersensitive to methylphenidate, and the accepted therapeutic range for adults is an overshoot. Juvenile treatment with MPH may result in long-lasting, potentially permanent, changes to excitatory neurons function in the prefrontal cortex of juvenile rats.” The study will appear in Biological Psychiatry.

Abstract → 

Distinct Age-Dependent Effects of Methylphenidate on Developing and Adult Prefrontal Neurons, Biological Psychiatry, available online 19 May 2012


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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].