Zoloft Causes Cells to Eat Themselves


Researchers at Princeton found that Zoloft accumulates in yeast cells, leading to curvature of the cellular membrane that triggers “autophagy,” wherein cells eat themselves as a protective measure. “So these SSRIs were supposed to be safe, and yet we’re finding that these yeast are overdosing quite strongly in response to Zoloft,” said one author. The finding suggests that Zoloft has unexpected side effects, given that yeast cells lack serotonin transporters. Results are in PLoS One.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].