Researchers at Princeton found that Zoloft accumulates in yeast cells, leading to curvature of the cellular membrane that triggers “autophagy,” wherein cells eat themselves as a protective measure. “So these SSRIs were supposed to be safe, and yet we’re finding that these yeast are overdosing quite strongly in response to Zoloft,” said one author. The finding suggests that Zoloft has unexpected side effects, given that yeast cells lack serotonin transporters. Results are in PLoS One.
Mad in America hosts blogs by a diverse group of writers. These posts are designed to serve as a public forum for a discussion—broadly speaking—of psychiatry and its treatments. The opinions expressed are the writers’ own.
I wonder what the implications of this are in humans. I know, let’s ask a depressed rat!