Researchers from Columbia and NYU found that stress sensitivity and impaired stress tolerance was greater in a cohort of 65 individuals deemed at high risk of psychosis, relative to controls. This tendency was associated over time with positive and negative symptoms, depression, anxiety and poor function. Life events were comparable in patients and controls, and was not associated with symptoms. Stress tolerance, symptoms, and function improved over time. Results appeared online June 1, 2012 in Psychological Medicine.