Withdrawal studies up to 9/23/2005

M.W. Agelink, A Zitselsberger, E. Kleiser, Withdrawal symptoms after discontinuation of Venlafaxine (letter), Am. J. Psychiatry, 154, 10, October 1997, 1473-1474.

G.W. Amsden, F. Georgian, Orthostatic hypotension induced by sertraline withdrawal, Pharmacotherapy, 1996, 16, 4, 684-686.

D.K. Arya, Withdrawal after discontinuation of paroxetine (letter), Aust NZ J Psychiatry, October 1996, 30 (5), 702

Bakker, Severe withdrawal symptoms with fever upon stopping paroxetine (letter, in Dutch), Ned Tijdschr Geneeskd, 28 August 1999, 143(35), 1795, discussion 1795-6.

L.C. Barr, W.K. Goodman, L.H. Price, Physical symptoms associated with paroxetine discontinuation (letter). Am J Psychiatry 1994 Feb, 151 (2), 289.

L. Belloeuf, C. Le Jeunne, F.C. Hugues, Paroxetine withdrawal syndrome [Article in French], Ann Med Interne (Paris) 2000 Apr;151 Suppl A:A52-3.

C.S. Berlin, Fluoxetine withdrawal symptoms. J Clin Psychiatry 1996 Feb, 57 (2), 93-4.

S. Bhuamik, H.J. Wildgust, Treatment outcomes including withdrawal phenomena with fluoxetine and paroxetine in patients with learning disabilities suffering from affective disorders (Letter), Human Psychopharmacology, 1996, 11, 337-338.

K, Black, C. Shea, S. Dursun, S Kutcher, Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria, J Psychiatry Neuroscience, 2000, 25(3), 255-261.

M. Bloch, S.V. Stager, A.R. Braun, D.R. Rubinow, Severe psychiatric symptoms associated with paroxetine withdrawal. Lancet 1995 Jul 1, 346 (8966), 57.

F. Bogetto, S. Bellino, R.B. Revello, L. Patria: Discontinuation syndrome in dysthymic patients with SSRIs: a clinical investigation, CNS Drugs, 2002, 16, 4, 273-283

I.W. Boyd, Venlafaxine withdrawal reactions, Med. J. Aust., 1998, July 20, 169(2), 91-92

Bryois, C Rubin, J.D.Zbinden, P. Baumann [Withdrawal syndrome caused by selective serotonin reuptake inhibitors: apropos of a case]. In German. Schweiz Rundsch Med Prax, 4 March 1998, 87:10, 345-348.

Dystonia and withdrawal symptoms with paroxetine (Seroxat). Current Problems in Pharmacovigilance 1993, February, 19, 1.

N.J. Coupland, C.J. Bell, Serotonin Reuptake Inhibitor Withdrawal, J. Clin. Psychopharmacol., 1996, 16, 3, 356-362

M.L. Dahl, E. Olhager, J. Ahlner, Paroxetine withdrawal syndrome in a neonate (letter), Br J Psychiatry, 1997, Oct, 171, 391-2.

A. Dallal, G. Chouinard: Withdrawal and rebound symptoms associated with abrubt discontinuation of venlafaxine (letter), J Clin Psychopharmacol, 1998, August, 18:4, 343-344.

C. Debattista, A.F. Schatzberg, Physical symptoms associated with paroxetine withdrawal (letter). Am J Psychiatry 1995 Aug, 152 (8), 1235-4.

R.S. Diler, L. Tamam, A. Avci: Withdrawal symptoms associated with paroxetine discontinuation in a nine-year-old boy. : J Clin Psychopharmacol 2000 Oct; 20(5):586-7

R.S. Diler, A. Avci, Selective Serotonin Reuptake Inhibitor Discontinuation Syndrome in Children: six case reports, Current Therapeutic Research, 2002 March, 63(2), 188-197.

S. C. Dilsaver, J.F. Greden, Antidepressant withdrawal phenomena, Biological Psychiatry, 1984, 19, 2, 237-256.

S. C. Dilsaver, Antidepressant withdrawal syndromes: phenomenology and pathophysiology, Acta Psychiatr. Scand., 1989, 79, 113-117.

Withdrawal phenomena associated with antidepressant and antipsychotic agents, Drug Safety, 1994, 10 (2), 103-114.

R.A. Dominguez, P.J. Goodnick, Adverse events after the abrupt discontinuation of paroxetine. Pharmacotherapy, 1995 Nov-Dec, 15 (6), 778-80.

J. Donoghue, P. Haddad: Pharmacists lack knowledge of antidepressant discontinuation symptoms [letter], J Clin Psychiatry 1999 Feb, 60:2, 124-5.

-Problems when withdrawing antidepressives, Drug & Ther. Bull., 1986, 21 April, 24, 29-30.

A Einarson, P Selby, G. Koren, Abrupt discontinuation of psychotropic drugs drug pregnancy: fear of teratogenic risk and impact of counselling, J. Psychiatry Neurosci 2001 January, 26(1), 44-48

M. Fagan, Withdrawal syndrome after the use of serotonin reuptake inhibitors (in Norwegian] Tidsskr Nor Laegeforen. 2000 Mar 20; 120(8):913-4.

A. Farah, T.E. Lauer, Possible venlafaxine withdrawal syndrome. Am J Psychiatry 1996 Apr, 153 (4), 576.

G.A. Fava, S. Grandi, Withdrawal syndromes after paroxetine and sertraline discontinuation (letter). J Clin Psychopharmacol 1995 Oct, 15 (5), 374-5

Favaro, S. Friederici, P. Santonastaso, Predictors of Sertraline Discontinuation Syndrome in Anorexia Nervosa, J Clin Psychopharmacol, 21(5), 2001 October, 533-535

O. Gerola et al., Antidepressant therapy in pregnancy: a review from the literature and report of a suspected paroxetine withdrawal syndrome in a newborn. Rivista Italiana di Pediatria, 1999, 25, 216-218

W.J. Giakas, J.M. Davis, Intractable withdrawal from venlafaxine treated with fluoxetine, Psychiatric Annals, February 1997, 27 (2), 85-86 and 92.

T.R. Goldstein, M.A. Frye, K.D. Denikoff, E. Smith-Jackson, G.S. Leverich, A.L. Bryan, S.O. Ali, R. M. Post: Antidepress and discontinuation-related manaia: critical prospective observation and theoretical implications in bipolar disorder, J. Clin Psychiatry, August 1999, 60(8), 563-567.

P. Haddad, M Lejoyeux, A Young, Antidepressant discontinuation reactions Are preventable and simple to treat, Brit Med J, 11 April 1998, 316, 1105-1106.

P. Haddad, Antidepressant discontinuation syndromes, Drug Safety, 2001, 24(3), 183-197.

P. Haddad, The SSRI discontinuation syndrome, J. Psychopharmacology, 1998, 12(3), 305-313.
Hindmarch, S. Kimber, S.M. Cockle: Abrupt and brief discontinuation of antidepressant treatment: effects on cognitive function and psychomotor performance, Int Clin Psychopharmacol 2000 Nov;15(6):305-18

S. Hirose, Restlessness related to SSRI withdrawal, Psychiatry and Clinical Neurosciences, 2001, 55, 79-80

Ibister GK, Dawson A, Whyte IM, Prior FH, Clancy C, Smith AJ, Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome? Arch Dis Child Fetal Ed, 2001, Sept, 85(2), F147-148

H. Johnson, W.P. Bouman, J. Lawton, Withdrawal reaction associated with venlafaxine, Brit. Med. J., 19 September 1998, 317, 787.

R. Judge, M.G. Parry, D. Quail, J.G. Jacobson, Discontinuation symptoms: comparison of brief interruption in fluoxetine and paroxetine treatment (sponsored by Eli Lilly), Int Clin Psychopharmacol, 2002, 17, 217-225.

Kasantikul, Reversible delirium after discontinuation of fluoxetine. J Med Assoc Thai 1995 Jan, 78 (1),.

N.J. Keuthen, P. Cyr, J.A. Ricciardi, et al,. Medication withdrawal symptoms in obsessive-compulsive disorder patients treated with paroxetine. J Clin Psychopharmacol 1994 Jun, 14 (3), 206-7.

M. Kotlyar, M. Golding, E.R. Brewer, S.W. Carson, Possible Nefazodone withdrawal syndrome (letter), Am J. Psychiatry, July 1999, 156(7), 1117.

P. Landry, L. Roy, Withdrawal hypomania associated with paroxetine, J. Clin. Psychopharmacol, 17, 1, February 1997, 60-61

R.M. Lane, Withdrawal symptoms after discontinuation of selective serotonin reuptake inhibitors, J. Serotonin Res., 1996, 3, 75-83.

C. Lauber: Nefazodone withdrawal symptoms, Can J Psychiatry, April 1999, 44(3), 285-286. Letter.

A.L. Lazowick, G.M. Levin, Potential withdrawal syndrome associated with SSRI discontinuation. Ann Pharmacother 1995 Dec, 29 (12), 1284-85.

F.L. Leiter, S.A. Nierenberg, K.M. Sanders, T.A. Stern, Discontinuation reactions following sertraline. Biol Psychiatry 1995 Nov 15, 38 (10), 694-5.

M. Lejoyeux, J. Ades, I. Mourad, J. Solomon and Steven Dilsaver, Antidepressant Withdrawal Syndrome – Recognition, Prevention and Management, CNS Drugs, 1996, April; 5, 4, 278-292

A.K. Louie, R.A. Lannon, L. J. Ajari, Withdrawal reaction after sertraline discontinuation (letter). Am J Psychiatry 1994 Mar, 151 (3), 450-1.

A.K. Louie, R.A. Lannon, M.A. Kirsch, T.B. Lewis, Venlafaxine withdrawal reactions (letter). Am J Psychiatry 1996 Dec, 153 (12), 1652.

C. Luckhaus, C. Jacob, Venlafaxine withdrawal syndrome not prevented by maprotiline, but resolved by sertraline (letter), Int J Neuropsychopharmacology, 2001, 4, 43-44.

C. Luckhaus, W.E. Müller, (in German) Withdrawal symptoms after prolonged intake of specific serotonin reuptake inhibitors, Psychopharmacotherapie, 2000, 7, 57-62

R. Macbeth, M. Rajagopalan, Venlafaxine withdrawal syndrome, Aust NZ J Med, 1998, 28, 218.

L. Macdonald: Discontinuation symptoms and SSRIs, CMAJ, 1998, Oct 6, 159(7), 846-847, and (in French) 850-852.

R. Mahendran, A. Chan, Selective Serotonin Reuptake Inhibitor Discontinuation Symptoms, Ann. Acad. Med. Singapore, 1999, July, 28, 596-599

S.M. Maixner, J.F. Greden: Extended antidepressant maintenance and discontinuation syndromes. Depress Anxiety 1998, 8 Suppl 1, 43-53

T.R. Mareth, T.M. Brown, SSRI withdrawal (letter). J Clin Psychiatry 1996 Jul, 57 (7), 310.

J.S. Markowitz: Selective serotonin reuptake inhibitor discontinuation with ECT and withdrawal symptoms (letter), J ECT, 1998, March, 14:1, 55

J.S. Markowitz: Nefazodone withdrawal symptoms, Can J Psychiatry, April 1999, 44(3), 286-287. Letter, Comment on Benazzi F., March 1998)

T. Mathew (Chair, ADRAC), SSRIs and withdrawal syndrome, Australian Adverse Drug Reactions Bulletin, 15, 1, November 1996, 2.

T. Mathew, SSRIs and neonatal disorders: Withdrawal reactions, Breast milk transfer, AADRB, 16, 4, November 1997, 14.

M. C. Miller, Symptoms that start when an antidepressant stops, Harvard Mental Health Letter, February 2001, 6-7.

I.J. Nijhuis, G.W. Kok-Van Rooij, A.N. Bosschaart, Withdrawal reactions of a premature neonate after maternal paroxetine (letter), Arch Dis Child Fetal Neonatal Ed 2001 January, 84(1): F77-78

H. Nordeng, R. Lindemann, K.V. Perminov, A. Reikvam, Neonatal withdrawal syndrome after in utero exposure to selective serotonin reuptake inhibitors, Acta Paediatr, 2001, 90, 288-291.

L Pacheco, P. Malo, E. Aragues, M. Etxebeste, More cases of paroxetine withdrawal syndrome, Brit J Psychiatry, Sept 1996, 169 (3), 384.

G. Parker, J. Blennerhassett: Withdrawal reactions associated with venlafaxine. Aust N Z J Psychiatry 1998 April, 32:2, 291-4.

F.P.M.L. Peeters, J Zandbergen, Violent withdrawal symptoms with fever while tapering off paroxetine (In Dutch, with English abstract); Ned. Tijdschr.Geneeskd, 1999, 3 July, 143 (27).

S.D. Phillips, A possible paroxetine withdrawal syndrome. Am J Psychiatry 1995, 152 (4), 645-6.

J.M. Plewes, S.C. Koke, M.E. Sayler, Adverse events and treatment discontinuations in fluoxetine clinical trials: an updated meta-analysis. European Neuropsychopharmacology, 7, S169, 1997.

B.G. Pollock: Discontinuation symptoms and SSRIs (letter), J Clin Psychiatry, 1998, Oct, 59:10, 535-537.

A comparison of the post-marketing safety of four selective serotonin reuptake inhibitors including the investigation of symptoms occurring on withdrawal, Br. J. Clin. Pharmacol., 1996, 42, 757-763.

R.E. Pyke, Paroxetine withdrawal syndrome. Am J Psychiatry 1995 Jan, 152 (1),149-50.

W. N. Raby, Treatment of venlafaxine discontinuation symptoms with odansetron (letter), J Clin Psychiatry, 1998, Nov, 59(11), 621-622.

M. Rajagopalan, J. Little, Discontinuation symptoms with nefazodone, Aust & NZ J. Psychiatry, 1999, 33, 594-597.

C. Rojas-Fernandez, J. Gordon: Selective serotonin reuptake inhibitor discontinuation syndrome: putative mechanisms and prevention strategies (letter), Can J Psychiatry, 1998, June, 43(5), 523-524.

J F Rosenbaum, M Fava, S L Hoog, R C Ascroft, W B Krebs: Selective Serotonin Reuptake Inhibitor Discontinuation Syndrome: A Randomised Clinical Trial, Biol Psychiatry, 1998, 44, 77-87.

J.E. Rosenblat, Toxicology and drug interactions: two more cases of fluoxetine withdrawal (and SSRI withdrawal symptoms online), Currents in Affective Illness, 1994, 13, 11, 15-17.

H.A. Rosenstock, Sertraline withdrawal in two brothers: a case report. Int Clin Psychopharmacol 1996 Mar, 11 (1), 58-9.

M. Schatzberg, P. Haddad, E.M. Kaplan, M. Lejoyeux, J.F. Rosenbaum, A.H. Young, J. Zajecka, Antidepressant Discontinuation Syndrome: update on serotonin reuptake inhibitors, J Clin Psychiatry, 1997, 58 (suppl 7), 1-4

E. Sempere, I Martinez, I Martinez-Mir, A Rey, Withdrawal syndrome and cytalopram (letter, in Spanish) Med Clin (Barc) 2000 March 11, 114(9): 359.

A.E. Shriver, G.S. Sachs et al., Mania and hypomania following antidepressant discontinuation, in New Research Program and Abstracts, Abstract NR 161:111, American Psychiatric Association, 151st Annual Meeting, Toronto, June 1998.

L. Sierra Santos, Y. Raigal Marin, A. Ortega Carcia, C. Berriochoa Martinez de Pison, G. Aparicio Jabalquinto: Venlafaxina y sindrome de discontinuacion, Atencion Primaria, December 1999, 24 (10), 115-116

M.M.S. Stahl, M. Lindquist, M. Pettersson, I.R. Edwards, J.H.Sanderson, N.F.Taylor, Withdrawal reactions with selective serotonin reuptake inhibitors (SSRIs) as reported to the WHO system, Eur. J. Clin. Pharmacol., (Accepted for publication, 1997)

J.A. Stiskal, N. Kulin, G. Koren, T. Ho, S. Ito: Neonatal paroxetine withdrawal syndrome (short report of four cases), Arch Dis Child

E. Szabadi, Fluvoxamine withdrawal syndrome. Brit J Psychiatry 1992 Feb, 160, 283-284.

F. Therrien, J.S. Markowitz: Selective serotonin reuptake inhibitors and withdrawal symptoms: a review of the literature, Human Psychopharmacology, 1997, 12, 309-323.

Thompson: Discontinuation of antidepressant therapy: emerging complications and their relevance. J Clin Psychiatry 1998 Oct, 59:10, 541-8

A.C Vergouwen, T. Kuipers, Severe withdrawal symptoms with fever upon stopping paroxetine (letter, in Dutch), Ned Tijdschr Geneeskd, 28 August 1999, 143(35), 1794-5, discussion 1795-6.

M. Walker-Kinnear, S. McNaughton, Paroxetine discontinuation syndrome in association with sertindole therapy, Brit J Psychiatry, April 1997, 170, 389.

World Health Organisation (Anon), Selective serotonin re-uptake inhibitors and withdrawal reactions, WHO Drug Information, 1998, 12, 3, 136-138

M. Z. Wincor: Withdrawal symptoms associated with abrupt discontinuation of SSRIs, J Am Pharm Assoc (Wash), 1998, July-August, 38(4), 500-501.

R.M. Wolfe, Antidepressant withdrawal reactions, American Family Physician, August 1997, 56 (2) (page numbers unknown).

A.H. Young, A Currie, Physicians’ knowledge of antidepressant withdrawal effects: a survey, J Clin Psychiatry, 1997, 58 (suppl 7), 28-30.

Young, P. Haddad: Discontinuation symptoms and psychotropic drugs (letter): The Lancet, 355, 1 April 2000, 1184

J. Zajecka, K.A. Tracy, S. Mitchell, Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review, J Clin. Psychiatry, July 1997, 58, 7, 291-297.


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