SSRIs Increase Risk of Brain Hemorrhage


Canadian researchers, publishing in Neurology, find in a meta-analysis of controlled observational studies comparing SSRI therapy with a control group that SSRI exposure increased the risk of intracerebral and intracranial hemorrhage by roughly 50%.

Abstract →

Hackam, D., Mrkobrada, M., Selective serotonin reuptake inhibitors and brain hemorrhage: A meta-analysis. Neurology. Published online before print October 17, 2012, doi: 10.1212/WNL.0b013e318271f848

Of Further Interest:
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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. Yet another article to tell us of the risks of SSRI’s. Problem is that I keep being told that those problems are solved by placing people on SNRI’s. The second generation of blockbuster antidepressents is not going to solve these problems, if anything the SNRI’s are more toxic and have more side effects, just like we now know about the second generation of antipsychotics. Why do people continue to believe that they can find happiness in a pill!!!

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  2. Oops sorry. I posted this reply to the wrong article. It’s supposed to be reply to the genetic marker article.

    By the way, SSRIs can cause haemorrhaging in the Gastrointestinal tract as well.
    Dalton SO, Johansen C, Mellemkjaer L, Nørgård B, Sørensen HT, Olsen JH. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study. Arch Intern Med. 2003 Jan 13;163(1):59-64.

    Alain Li Wan Po, Antidepressants and upper gastrointestinal bleeding BMJ. 1999 October 23; 319(7217): 1081–1082.

    Gastrointestinal bleeding was added as a side effect on UK patient information leaflets (PILS) for Seroxat in June 2003, after the BBC Panorama programmes.

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