Researchers (including Jim van Os) find, in a three-year cohort study of 1272 people at possible genetic risk of psychosis, that “most transitions (to psychosis) can be attributed to powerful environmental effects that become detectable when analysed against elevated background genetic risk, indicating gene-environment interaction.” The authors conclude “Environmental risk associated with transition to psychotic disorder is semi-ubiquitous regardless of genetic high risk status.”
van Nierop, M., Janssens, M., Bruggeman, R., Cahn, W.; Evidence That Transition from Health to Psychotic Disorder Can Be Traced to Semi-Ubiquitous Environmental Effects Operating against Background Genetic Risk. PLoS One. Nov 06, 2013; DOI: 10.1371/journal.pone.0076690
Of further interest:
Environment plays primary role in psychosis transition (MedWire)