Researchers from Australia find that chronic treatment with SSRIs significantly increases the rate of epileptogenesis in rats. Although SSRIs are commonly prescribed to people with epilepsy due to its high comorbidity with depression, they say, no previous studies have investigated the effects of SSRIs on epileptogenesis. Results appeared online in the journal Neurobiology of Disease.
Cardamone, L., Salzburg, M., Koe, A., Ozturk, E., O’Brien, T., Jones, N.; Chronic antidepressant treatment accelerates kindling epileptogenesis in rats. Neurobiology of Disease. Online December 7, 2013.