SSRIs Cause Epilepsy in Rats

Kermit Cole
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Researchers from Australia find that chronic treatment with SSRIs significantly increases the rate of epileptogenesis in rats.  Although SSRIs are commonly prescribed to people with epilepsy due to its high comorbidity with depression, they say, no previous studies have investigated the effects of SSRIs on epileptogenesis.  Results appeared online in the journal Neurobiology of Disease.

Abstract →

Cardamone, L., Salzburg, M., Koe, A., Ozturk, E., O’Brien, T., Jones, N.; Chronic antidepressant treatment accelerates kindling epileptogenesis in rats. Neurobiology of Disease. Online December 7, 2013.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]

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