Antipsychotics Ineffective Against Cocaine, Stimulant Addictions


Although cocaine and psychostimulant dependence are thought to be related to increased dopamine release, research from Tokyo and Long Island finds that the effect of antipsychotics did not differ from that of a placebo in regard to cocaine, amphetamine and methamphetamine use, addiction, craving, depression, anxiety, or abstinence.  Antipsychotics were discontinued more than placebo, as a result of intolerability, leading to antipsychotics being outperformed by placebo in some measures.

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. How many millions did they spend to figure out drugs that make people feel like tired zombies won’t make them not crave stimulants ?

    Can I have a million dollars to see if dry hot weather prevents people from getting thirsty ???

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  2. If you take antidopaminergics, you need/want more dopamine.
    If you need/want dopamine, you take stimulants.
    This could be the same with nicotine.

    (Of course this is VERY simplified but why nobody cares it this time?)

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