Lack of Evidence for Psychotropic Polypharmacy


Although combining psychotropic medications is common, according to research in Current Opinion in Psychiatry, evidence regarding polypharmacy approaches remains unsupported by evidence.

Abstract →

Ballon, J, Stroup, T.S.; Polypharmacy for Schizophrenia. Current Opinion in Psychiatry. Online January 11, 2013. doi: 10.1097/YCO.0b013e32835d9efb

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected].


  1. The road to psychiatric nightmare hell is paved with “looking for the right combination of meds”.

    A net Poster writes: “I started trying when I was 17 and I’m now 33 and still searching. I’m really not trying to discourage you. I know a lot of people who felt better after trying one or two. Don’t give up. ”

    “Don’t give up”

    WHAT ?????


    Most psychiatric fundamentalists online will write about treatments and doctors and trying and not giving up and hope. When of course the secret is that they have none of their own. They do believe that others should continue. They believe in the religion of psychiatry, but not for themselves…no, they don’t think they can be “saved”. They play the victim role, or the martyr role. They spend each day trying to prove that there is hope in psychiatry, while believing it will work for others even when it doesn’t work for them. They’re too broken, too “sick”. “It doesn’t work for me, and all these nasty “anti-psychiatry” people say it didn’t work for them, but YOU should keep trying, and I will keep trying too, because I have been convinced that it’s the appropriate course of action.”


    “You just need to find the right combination of meds…” Polypharmacy.

    Has any other advice ruined more lives ???

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