Fluoxetine in Adolescence Raises Sensitivity to Stress in Adults

Kermit Cole
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Research on neurochemicals associated with moods in mice and rats finds that, while less depression-like behavior was observed in those receiving fluoxetine (Prozac) administration in adolescence (compared to those receiving a placebo), sensitivity to anxiety was more pronounced in adulthood. The study, appearing in the Journal of Neuroscience, shows “the complexity of drug and intracellular manipulations in the immature brain,” according to the authors.

Abstract →

Iñiguez, S., Alcantara, L., Warren, B., Riggs, L.; Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood. Journal of Neuroscience. Online January 15, 2014. 34(3): 1007-1021; doi: 10.1523/JNEUROSCI.5725-12.2014

Of further interest:
Prozac during adolescence protects against despair in adulthood (LA Times)

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Kermit Cole
Kermit Cole, MFT, founding editor of Mad in America, works in Santa Fe, New Mexico as a couples and family therapist. Inspired by Open Dialogue, he works as part of a team and consults with couples and families that have members identified as patients. His work in residential treatment — largely with severely traumatized and/or "psychotic" clients — led to an appreciation of the power and beauty of systemic philosophy and practice, as the alternative to the prevailing focus on individual pathology. A former film-maker, he has undergraduate and master's degrees in psychology from Harvard University, as well as an MFT degree from the Council for Relationships in Philadelphia. He is a doctoral candidate with the Taos Institute and the Free University of Brussels. You can reach him at [email protected]

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