Research on neurochemicals associated with moods in mice and rats finds that, while less depression-like behavior was observed in those receiving fluoxetine (Prozac) administration in adolescence (compared to those receiving a placebo), sensitivity to anxiety was more pronounced in adulthood. The study, appearing in the Journal of Neuroscience, shows “the complexity of drug and intracellular manipulations in the immature brain,” according to the authors.
Iñiguez, S., Alcantara, L., Warren, B., Riggs, L.; Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood. Journal of Neuroscience. Online January 15, 2014. 34(3): 1007-1021; doi: 10.1523/JNEUROSCI.5725-12.2014
Of further interest:
Prozac during adolescence protects against despair in adulthood (LA Times)